RNA - Martin Lab

A New Approach to RNA Synthesis: Immobilization of Stably and Functionally Co-Tethered Promoter DNA and T7 RNA Polymerase

By Martin Posted on July 1, 2024 Posted in Publications, Uncategorized Tagged with in vitro, RNA, rna polymerase, RNA synthesis, T7 RNA polymerase, transcription

Kithmie MalagodaPathiranage, Ruptanu Banerjee, and Craig T. Martin, Nucleic Acids Research, July, 2024 Current approaches to RNA synthesis/manufacturing require substantial (and incomplete) purification post-synthesis. We have previously demonstrated the synthesis of RNA from a complex in which T7 RNA polymerase is …

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Efficient inhibition of RNA self-primed extension by addition of competing 3’-capture DNA – improved RNA synthesis by T7 RNA polymerase

By Martin Posted on August 8, 2019 Posted in Publications Tagged with in vitro, RNA, rna polymerase, RNA synthesis, T7 RNA polymerase, transcription

Yasaman Gholamalipour, William C. Johnson, & Craig T. Martin, Nucl Acids Res, 47, e118 (7 pages). 2019 In vitro synthesized RNA is used widely in studies of RNA biology, biotechnology and RNA therapeutics. However, in vitro synthesized RNA often contains impurities, such as …

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A New Approach to RNA Synthesis: Immobilization of Stably and Functionally Co-Tethered Promoter DNA and T7 RNA Polymerase

Efficient inhibition of RNA self-primed extension by addition of competing 3’-capture DNA – improved RNA synthesis by T7 RNA polymerase