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    • RNA – Opportunities & Challenges
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    • T7 RNA Polymerase
      • Quick Intro
      • Transcription - a general overview
      • Mechanism and Structure
        • Mechanism and Structure
        • Promoter Binding
        • Elongation complex stability
      • Interactive structures
        • Structure - Initiation
        • Structure - initially transcribing
        • Structure - elongation
        • T7 RNA polymerase family
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      • Transcription simulation – gel analysis
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      • Intro to Nucleic Acids
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        • Word Tips – Embedding Figures
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        • RNASq – Seq Analysis Tools
        • Set up exptparams
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      • Phosphoramidite Synthesis Cycle
      • Quantifying gels
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RNA

Central to Life's Central Dogma - and to New Therapeutic Modalities!

The Martin Lab at UMass Amherst
is excited about RNA and its applications (vaccines, but much more!). With our deep understanding of T7 RNA polymerase, we are developing next generation RNA manufacturing, to drive rapid expansion in fundamental RNA biology, biotechnology, and RNA vaccines and therapeutics (including mRNA, CRISPR, lncRNA, and more!).

  • UMass Old Chapel in the Fall
  • Central Dogma Revisited
  • In this lab, we believe ... science is real, humanity is important.
  • ribonicleic acid chain from which the deoxyribonucleic acid or DNA is composed - 3d illustration
  • Functionally co-tethered polymerase and DNA allows multiple rounds of hight salt, repeat-batch transcription
    Functionally co-tethered transcription, at high salt

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