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Martin Lab

Novel RNA Manufacturing

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    • RNA – Opportunities & Challenges
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    • T7 RNA Polymerase
      • Transcription – a quick overview
      • Mechanism and Structure
        • Mechanism and Structure
        • Promoter Binding
        • Elongation complex stability
      • Interactive structures
        • Structure – Initiation
        • Structure – initially transcribing
        • Structure – elongation
        • T7 RNA polymerase family
    • Practical Thoughts
      • Transcription simulation – gel analysis
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        • Word Tips – Embedding Figures
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        • RNASq – Seq Analysis Tools
        • Set up exptparams
        • RNASq Quick Start
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        • R – fitting data to a mathematical model
      • Phosphoramidite Synthesis Cycle
      • Quantifying gels
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RNA

Central to Life's Central Dogma

The Martin Lab at UMass Amherst
is excited about RNA and its applications (vaccines, but much more!). With our deep understanding of T7 RNA polymerase, we now aim to improve the enzymatic synthesis/manufacturing of RNA, to further enable researchers in fundamental RNA biology, biotechnology, and to develop next generation manufacturing of RNA vaccines and therapeutics.

  • UMass Old Chapel in the Fall
  • Central Dogma Revisited

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