The Martin Lab at UMass Amherst
Craig, Will, Kira, Elvan, Kyle, Kithmie, Yasi, & Amelia (missing from photo) - is excited about all things RNA. We strive to understand mechanism in the complex process of transcription, and we exploit our deep mechanistic understandings towards improving applications of the model enzyme T7 RNA polymerase. Specifically, we now aim to improve the enzymatic synthesis of RNA, to further enable researchers in fundamental RNA biology, biotechnology, and next generation RNA therapeutics. And we've got exciting new results coming out soon - stay tuned here!
Have you used T7 RNA polymerase to synthesize RNA? Have you encountered low yields, undesired products, or other problems? Your problems may contribute to our mechanistic insights, and perhaps, to improvements in synthesis approaches.