T7 RNA polymerase family



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Sequence conservation as determined by ConSURF analysis (accepting all default analysis parameters).

Remember that some key amino acids, for example, those involved in species-specific promoter recognition, may not score as highly conserved. Active site catalytic residues, on the other hand, are very highly conserved.

MM 1 – 73% M, 18% W, 9% F NN 2 – 65% N, 6% Q, 12% S, 6% A, 12% T TT 3 – 10% Q, 10% A, 15% T, 5% I, 60% V II 4 – 83% I, 13% L, 4% V NN 5 – 14% K, 4% H, 4% D, 11% E, 36% N, 21% Q, 7% S, 4% A- II 6 – 3% K, 16% A, 3% T, 6% F, 28% I, 9% L, 22% V, 13% P AA 7 – 3% K, 8% D, 24% E, 5% N, 8% Q, 18% A, 3% G, 13% T, 3% I, 3% V, 13% P KK 8 – 54% K, 22% R, 2% Q, 2% S, 7% A, 7% L, 4% V, 2% P NN 9 – 43% H, 46% N, 9% Q, 2% L DD 10 – 89% D, 11% N- FF 11 – 100% F SS 12 – 11% D, 2% E, 85% S, 2% T DD 13 – 2% H, 76% D, 20% E, 2% A II 14 – 4% M, 65% I, 2% L, 28% V EE 15 – 23% K, 3% R, 34% E, 3% Q, 26% S, 3% A, 3% G, 3% T, 3% I- LL 16 – 17% K, 2% R, 11% H, 11% E, 26% N, 2% Q, 2% A, 2% T, 2% I, 22% L, 2% V AA 17 – 2% K, 2% D, 2% N, 28% S, 52% A, 13% T AA 18 – 2% K, 2% D, 2% Q, 23% S, 21% A, 11% T, 23% I, 6% V, 9% P II 19 – 4% K, 19% E, 6% Q, 2% S, 2% A, 2% G, 4% M, 2% T, 30% W, 23% I, 2% L, 2% P PP 20 – 44% A, 56% P 20
FF 21 – 2% Q, 2% S, 2% A, 20% Y, 70% F, 4% L NN 22 – 4% K, 2% R, 11% D, 25% E, 45% N, 4% Q, 4% A, 5% T TT 23 – 2% K, 2% E, 2% N, 2% Q, 5% A, 2% G, 2% M, 47% T, 16% I, 7% L, 13% V LL 24 – 7% M, 2% F, 92% L AA 25 – 5% K, 2% E, 34% S, 47% A, 2% M, 2% T, 3% I, 2% L, 3% V- DD 26 – 8% K, 7% R, 2% H, 39% D, 15% E, 7% N, 3% Q, 7% S, 8% A, 3% G HH 27 – 7% K, 27% H, 2% E, 2% N, 2% Q, 2% S, 7% A, 5% M, 2% T, 12% I, 34% L YY 28 – 2% E, 2% W, 88% Y, 8% F GG 29 – 2% E, 2% N, 95% G, 2% T EE 30 – 5% D, 46% E, 2% N, 8% Q, 8% S, 9% A, 2% G, 5% T, 2% V, 15% P- RR 31 – 1% K, 6% R, 4% H, 41% D, 25% E, 3% N, 6% Q, 1% S, 7% A, 1% T, 1% Y, 1% V LL 32 – 1% K, 1% R, 1% A, 4% M, 3% I, 90% L AA 33 – 4% R, 71% A, 6% M, 1% W, 5% Y, 5% F, 4% I, 4% V RR 34 – 5% K, 8% R, 5% D, 16% E, 4% Q, 6% S, 44% A, 6% T, 1% L, 5% V, 1% P EE 35 – 10% K, 21% R, 1% D, 24% E, 7% Q, 1% S, 13% A, 12% T, 3% I, 1% L, 6% V- QQ 36 – 3% E, 97% Q LL 37 – 2% R, 1% E, 5% A, 1% M, 1% W, 12% I, 71% L, 7% V AA 38 – 3% K, 9% R, 3% H, 3% D, 21% E, 19% Q, 7% S, 27% A, 1% G, 3% M, 1% T, 2% L LL 39 – 1% K, 4% I, 95% L EE 40 – 100% E 40
HH 41 – 3% K, 2% R, 47% H, 2% D, 21% E, 5% Q, 1% S, 9% A, 1% T, 1% Y, 1% F, 3% I, 3% L EE 42 – 4% K, 5% R, 2% D, 84% E, 2% S, 2% G SS 43 – 20% S, 44% A, 4% G, 29% M, 3% Y YY 44 – 5% K, 14% R, 11% H, 1% Q, 5% S, 4% A, 9% T, 43% Y, 1% I, 3% L, 3% V EE 45 – 1% K, 1% D, 17% E, 4% N, 9% Q, 14% S, 3% A, 1% C, 5% G, 3% M, 36% T, 1% L, 4% V- MM 46 – 8% R, 1% D, 14% E, 4% S, 5% A, 2% G, 10% M, 2% F, 5% I, 47% L, 1% V GG 47 – 4% A, 96% G EE 48 – 3% R, 52% E, 4% S, 13% A, 2% T, 18% I, 8% V AA 49 – 13% K, 6% R, 16% D, 27% E, 1% N, 9% Q, 2% S, 25% A, 1% L RR 50 – 9% K, 80% R, 1% H, 3% N, 2% Q, 2% A, 2% L- FF 51 – 1% H, 17% Y, 77% F, 3% L, 2% V RR 52 – 7% K, 20% R, 9% H, 1% D, 7% E, 3% N, 5% Q, 2% A, 3% M, 1% T, 5% W, 1% Y, 7% I, 26% L, 1% V KK 53 – 64% K, 15% R, 2% D, 3% E, 2% N, 2% Q, 4% S, 6% A, 2% M MM 54 – 3% R, 4% D, 5% E, 18% N, 15% Q, 2% S, 26% A, 5% G, 9% M, 5% T, 5% I, 1% L, 1% V FF 55 – 1% H, 1% N, 7% A, 13% M, 3% T, 4% Y, 5% F, 2% I, 51% L, 12% V- EE 56 – 1% R, 10% D, 55% E, 8% N, 5% Q, 5% S, 4% A, 1% G, 2% T, 1% Y, 1% I, 5% L RR 57 – 21% K, 54% R, 8% E, 2% N, 2% Q, 2% S, 7% A, 1% T, 3% F QQ 58 – 5% K, 1% R, 1% D, 1% E, 5% N, 41% Q, 9% S, 31% A, 2% G, 1% M, 1% T, 1% Y LL 59 – 4% K, 18% R, 1% H, 1% E, 4% Q, 2% S, 16% A, 10% M, 3% T, 27% I, 3% L, 11% V KK 60 – 13% K, 1% R, 10% D, 47% E, 2% N, 13% Q, 5% A, 2% G, 3% T, 1% I, 2% L, 1% V 60
AA 61 – 7% K, 39% R, 2% D, 10% E, 6% N, 4% Q, 4% S, 20% A, 1% G, 1% M, 3% T, 1% F GG 62 – 3% K, 2% R, 1% H, 5% E, 6% N, 3% Q, 2% S, 2% A, 73% G, 1% L EE 63 – 1% K, 9% R, 9% D, 52% E, 2% N, 17% Q, 1% S, 5% A, 2% T, 2% V VV 64 – 26% E, 8% A, 5% G, 3% M, 2% T, 3% Y, 28% F, 2% I, 9% L, 13% V AA 65 – 1% K, 1% H, 8% D, 2% E, 2% N, 15% S, 47% A, 9% G, 14% T, 1% I- DD 66 – 4% R, 46% D, 11% E, 5% N, 5% Q, 13% S, 2% A, 9% G, 1% M, 3% T NN 67 – 3% H, 2% D, 36% N, 1% Q, 11% S, 1% G, 36% T, 2% I, 3% L, 3% V AA 68 – 4% K, 10% R, 1% D, 2% E, 1% N, 7% Q, 13% S, 29% A, 7% G, 2% M, 6% T, 7% L, 6% V, 3% P AA 69 – 14% S, 22% A, 1% G, 10% T, 11% Y, 1% I, 3% L, 26% V, 11% P AA 70 – 3% S, 50% A, 25% G, 3% M, 2% Y, 1% F, 1% I, 1% L, 14% V- KK 71 – 49% K, 20% R, 3% N, 13% Q, 4% S, 1% A, 2% G, 5% T, 1% L, 1% V
RNA exit channel
PP 72 – 6% K, 20% R, 1% N, 6% Q, 1% S, 1% A, 1% G, 4% T, 4% W, 2% Y, 1% I, 1% L, 52% P LL 73 – 3% M, 1% F, 18% I, 64% L, 14% V II 74 – 1% A, 14% M, 1% T, 3% F, 18% I, 34% L, 29% V TT 75 – 8% K, 3% R, 1% H, 6% D, 5% E, 9% N, 8% Q, 14% S, 21% A, 5% G, 2% M, 7% T, 4% I, 3% L, 2% V- TT 76 – 1% K, 4% R, 13% H, 5% D, 10% E, 2% Q, 7% S, 10% A, 6% G, 4% M, 27% T, 2% L, 7% V LL 77 – 8% R, 1% H, 1% D, 3% Q, 5% S, 12% A, 3% G, 3% T, 3% I, 55% L, 5% V LL 78 – 12% H, 3% A, 3% M, 2% Y, 2% F, 29% I, 13% L, 35% V PP 79 – 2% K, 8% D, 12% E, 1% N, 3% S, 6% A, 1% G, 4% T, 1% I, 2% L, 2% V, 57% P KK 80 – 27% K, 11% R, 1% D, 2% N, 7% Q, 1% S, 7% A, 2% G, 8% M, 3% T, 2% I, 12% L, 1% V, 14% P 80
MM 81 – 1% A, 14% M, 6% T, 1% Y, 14% F, 5% I, 32% L, 26% V II 82 – 2% R, 2% E, 2% Q, 18% S, 36% A, 2% M, 10% T, 2% F, 6% I, 1% L, 19% V AA 83 – 14% K, 3% D, 21% E, 4% N, 8% Q, 4% S, 30% A, 3% G, 1% M, 10% T, 1% V RR 84 – 3% K, 22% R, 2% H, 5% E, 2% N, 1% S, 52% A, 1% C, 11% G, 1% Y II 85 – 1% H, 5% M, 1% T, 1% W, 8% Y, 8% F, 57% I, 10% L, 8% V- NN 86 – 12% K, 3% R, 2% H, 14% D, 20% E, 11% N, 2% S, 7% A, 1% G, 1% M, 16% T, 1% I, 4% L, 3% V, 1% P DD 87 – 7% K, 10% D, 31% E, 7% N, 5% Q, 2% S, 25% A, 1% G, 6% T, 1% I, 3% L, 1% V WW 88 – 1% K, 60% W, 1% Y, 37% F, 1% L FF 89 – 9% K, 7% R, 4% H, 1% E, 1% Q, 1% C, 6% M, 3% T, 1% W, 6% F, 14% I, 22% L, 24% V EE 90 – 3% K, 4% H, 18% D, 44% E, 2% N, 1% S, 21% A, 5% T, 1% I, 1% V- EE 91 – 6% K, 20% H, 8% D, 40% E, 2% N, 4% S, 6% A, 1% G, 1% M, 6% T, 1% F, 1% L, 2% V, 1% P VV 92 – 2% K, 1% H, 2% E, 27% Q, 6% S, 34% A, 4% C, 1% G, 2% M, 7% T, 1% W, 1% Y, 1% F, 1% I, 1% L, 6% V, 1% P KK 93 – 12% K, 2% R, 4% D, 4% E, 9% N, 3% Q, 29% S, 10% A, 5% G, 6% M, 4% T, 11% V, 1% P AA 94 – 3% K, 1% R, 1% H, 4% E, 5% N, 1% Q, 5% S, 6% A, 47% G, 16% T, 1% L, 1% V, 7% P KK 95 – 72% K, 9% R, 1% H, 1% N, 2% Q, 2% S, 8% A, 2% T, 2% V- RR 96 – 8% K, 14% R, 1% D, 5% S, 26% A, 5% G, 1% M, 1% T, 1% L, 22% V, 15% P GG 97 – 1% K, 23% R, 1% H, 1% D, 4% S, 69% G, 1% P KK 98 – 28% K, 53% R, 2% H, 2% N, 1% Q, 3% A, 1% C, 1% T, 6% V, 3% P RR 99 – 56% K, 31% R, 4% N, 1% S, 2% A, 1% M, 1% W, 1% L, 3% P PP 100 – 45% H, 4% N, 1% Q, 20% S, 6% A, 2% G, 3% T, 1% Y, 1% V, 16% P 100
TT 101 – 4% K, 1% R, 1% H, 1% Q, 12% S, 12% A, 2% G, 21% T, 4% I, 3% L, 37% V, 1% P AA 102 – 1% Q, 9% S, 73% A, 3% G, 1% M, 2% T, 3% Y, 1% I, 4% L, 2% V FF 103 – 1% K, 1% R, 1% N, 4% Q, 8% A, 1% G, 2% M, 2% T, 4% W, 14% Y, 7% F, 9% I, 25% L, 20% V QQ 104 – 30% K, 19% R, 2% D, 2% E, 3% N, 6% Q, 4% S, 7% A, 6% G, 3% T, 3% Y, 3% L, 4% V, 7% P FF 105 – 7% K, 3% H, 1% D, 1% E, 6% A, 4% M, 2% T, 3% W, 20% Y, 26% F, 8% I, 15% L, 1% V, 2% P- LL 106 – 2% A, 2% M, 5% T, 23% F, 24% I, 37% L, 7% V QQ 107 – 16% K, 16% R, 1% H, 4% D, 9% E, 3% N, 23% Q, 6% S, 9% A, 1% G, 1% M, 2% T, 1% F, 1% I, 5% L EE 108 – 16% K, 4% H, 16% D, 7% E, 3% N, 12% Q, 6% S, 2% A, 12% G, 9% M, 6% T, 3% L, 1% V
Begin insertion
II 109 – 1% K, 1% D, 1% E, 1% Q, 2% A, 1% C, 14% M, 4% T, 1% Y, 3% F, 20% I, 24% L, 27% V KK 110 – 16% K, 3% R, 28% D, 8% E, 15% N, 8% S, 4% A, 2% G, 1% M, 3% T, 3% L, 7% P- PP 111 – 1% R, 2% H, 2% D, 1% N, 10% S, 24% A, 1% C, 2% G, 1% M, 3% T, 4% Y, 1% I, 3% L, 6% V, 38% P EE 112 – 5% K, 1% R, 3% H, 22% D, 48% E, 2% N, 2% Q, 3% S, 3% A, 1% M, 6% T, 1% L, 1% V, 1% P AA 113 – 5% K, 10% R, 4% E, 5% N, 1% Q, 8% S, 17% A, 5% M, 11% T, 2% I, 8% L, 22% V VV 114 – 1% S, 18% A, 2% C, 4% M, 10% I, 29% L, 36% V AA 115 – 3% S, 93% A, 4% T- YY 116 – 6% H, 4% N, 3% S, 19% A, 1% M, 1% T, 18% Y, 29% F, 2% I, 6% L, 10% V II 117 – 1% S, 3% A, 56% I, 28% L, 12% V TT 118 – 1% S, 17% A, 4% G, 68% T, 2% I, 1% L, 5% V, 1% P II 119 – 1% S, 9% A, 2% C, 1% M, 2% T, 3% F, 33% I, 36% L, 13% V KK 120 – 63% K, 31% R, 1% N, 4% S, 1% F 120
TT 121 – 6% R, 7% H, 1% E, 4% N, 2% Q, 4% S, 7% A, 4% C, 1% G, 1% M, 18% T, 4% W, 6% I, 9% L, 24% V TT 122 – 1% S, 8% A, 8% C, 2% G, 1% M, 13% T, 12% I, 10% L, 44% V LL 123 – 5% M, 5% F, 13% I, 72% L, 4% V AA 124 – 2% K, 19% D, 28% N, 18% S, 14% A, 8% G, 1% M, 8% T, 1% V CC 125 – 6% K, 7% R, 1% H, 2% D, 9% E, 3% N, 3% Q, 9% S, 15% A, 7% C, 18% G, 5% M, 5% T, 1% Y, 3% I, 4% L- LL 126 – 3% S, 5% A, 2% C, 8% M, 3% Y, 3% F, 20% I, 36% L, 19% V TT 127 – 1% H, 19% S, 34% A, 2% C, 2% G, 6% M, 21% T, 1% F, 4% I, 3% L, 6% V SS 128 – 24% K, 16% R, 2% D, 3% N, 13% Q, 16% S, 7% A, 4% G, 2% M, 3% T, 1% Y, 5% L, 2% V AA 129 – 16% K, 17% R, 3% D, 9% E, 3% N, 8% Q, 4% S, 6% A, 5% G, 2% M, 9% T, 3% L, 3% V, 10% P
Begin insertion
DD 130 – 6% K, 12% D, 28% E, 6% N, 12% S, 4% A, 20% G, 2% T, 2% L, 4% V, 4% P- NN 131 – 3% K, 7% R, 6% H, 10% D, 7% E, 3% N, 4% Q, 4% S, 13% A, 7% G, 4% M, 3% T, 1% Y, 3% F, 1% I, 3% L, 3% V, 16% P TT 132 – 1% K, 12% R, 2% H, 3% D, 1% E, 1% N, 9% Q, 11% S, 6% A, 1% C, 1% G, 3% M, 16% T, 3% I, 7% L, 14% V, 7% P TT 133 – 9% K, 5% R, 1% H, 3% D, 1% E, 11% N, 1% Q, 11% S, 1% A, 1% M, 33% T, 2% F, 2% L, 5% V, 13% P VV 134 – 3% N, 4% A, 4% M, 2% Y, 2% F, 20% I, 36% L, 28% V, 1% P QQ 135 – 45% Q, 5% S, 3% A, 1% G, 29% T, 4% I, 12% V, 1% P- AA 136 – 5% K, 10% R, 2% H, 2% D, 6% E, 11% N, 4% Q, 13% S, 20% A, 3% G, 1% M, 3% T, 3% Y, 4% F, 2% V, 9% P VV 137 – 2% S, 5% A, 1% C, 7% M, 8% T, 7% I, 24% L, 45% V AA 138 – 2% N, 14% S, 64% A, 2% C, 7% G, 1% M, 7% T, 1% Y, 1% V SS 139 – 1% K, 7% R, 4% E, 5% N, 3% Q, 11% S, 1% A, 1% C, 6% G, 4% M, 7% T, 3% Y, 2% F, 13% I, 6% L, 24% V AA 140 – 8% K, 21% R, 2% H, 1% D, 1% E, 3% N, 5% Q, 17% S, 26% A, 1% G, 1% M, 7% T, 1% W, 1% F, 2% L, 2% V 140
II 141 – 74% I, 13% L, 12% V GG 142 – 2% N, 1% S, 16% A, 80% G, 1% T RR 143 – 14% K, 28% R, 3% H, 1% D, 4% N, 6% Q, 16% S, 4% A, 8% G, 5% M, 5% T, 1% Y, 2% L, 2% V AA 144 – 1% R, 8% D, 6% E, 3% N, 15% S, 32% A, 3% G, 10% M, 15% T, 4% L, 2% V II 145 – 4% M, 47% I, 28% L, 21% V- EE 146 – 3% D, 86% E, 5% Q, 3% A, 1% M, 1% Y, 1% F DD 147 – 59% D, 24% E, 6% N, 1% M, 5% T, 4% L EE 148 – 92% E, 4% Q, 3% S, 1% C AA 149 – 3% K, 1% H, 1% Q, 33% A, 2% C, 11% M, 2% T, 1% Y, 4% F, 14% I, 22% L, 5% V RR 150 – 1% K, 76% R, 1% H, 1% E, 10% N, 2% Q, 1% S, 4% A, 1% Y, 2% F, 1% V- FF 151 – 4% S, 3% A, 1% M, 13% Y, 67% F, 1% I, 10% L GG 152 – 13% R, 6% D, 3% E, 4% N, 11% S, 8% A, 50% G, 4% T RR 153 – 9% K, 60% R, 2% H, 1% D, 4% E, 1% N, 1% Q, 2% S, 11% A, 1% G, 2% T, 1% Y, 4% L II 154 – 1% M, 2% Y, 28% F, 51% I, 14% L, 4% V RR 155 – 8% K, 68% R, 7% E, 1% Q, 1% S, 4% A, 4% M, 5% L, 1% V- DD 156 – 5% K, 1% R, 37% D, 33% E, 1% N, 1% Q, 3% S, 8% A, 4% G, 1% T, 2% I, 4% V LL 157 – 5% K, 2% H, 3% D, 26% E, 3% N, 24% Q, 4% S, 9% A, 2% M, 4% T, 2% F, 12% L, 3% V EE 158 – 1% K, 3% H, 10% D, 58% E, 12% N, 1% Q, 2% S, 2% A, 5% M, 2% Y, 1% F, 2% L AA 159 – 11% K, 9% R, 1% D, 7% E, 11% Q, 1% S, 30% A, 3% G, 1% M, 2% I, 2% V, 21% P KK 160 – 41% K, 3% R, 10% D, 12% E, 1% N, 4% Q, 2% S, 12% A, 12% G, 1% F, 1% V 160
HH 161 – 5% K, 3% R, 38% H, 1% E, 3% N, 1% Q, 17% A, 1% M, 2% T, 9% Y, 5% F, 1% I, 12% L, 1% V FF 162 – 3% K, 6% H, 1% E, 1% A, 3% M, 1% T, 1% W, 31% Y, 50% F, 2% L, 1% V KK 163 – 43% K, 7% R, 1% H, 6% D, 10% E, 9% N, 9% Q, 3% S, 6% A, 2% G, 1% M, 1% T, 1% P
Begin insertion
KK 164 – 47% K, 12% R, 4% H, 1% D, 3% E, 3% N, 5% Q, 2% S, 4% A, 5% G, 4% T, 3% W, 1% Y, 1% F, 1% I, 3% V NN 165 – 2% K, 14% R, 33% H, 18% N, 7% A, 2% C, 4% T, 9% Y, 7% F, 5% V- VV 166 – 5% A, 2% M, 3% T, 3% F, 38% I, 16% L, 33% V EE 167 – 15% K, 17% R, 1% H, 3% D, 16% E, 11% Q, 10% A, 3% M, 3% T, 1% Y, 1% I, 6% L, 11% V EE 168 – 26% K, 6% R, 11% D, 22% E, 5% Q, 1% S, 4% A, 3% G, 4% T, 2% I, 1% L, 2% V, 12% P QQ 169 – 9% K, 5% R, 1% H, 7% D, 1% E, 10% N, 15% Q, 3% S, 23% A, 20% G, 1% W, 3% V LL 170 – 3% E, 1% Q, 12% A, 1% T, 14% I, 63% L, 5% V- NN 171 – 28% K, 1% R, 13% D, 6% E, 30% N, 3% Q, 3% S, 9% A, 2% G, 4% T, 1% L KK 172 – 63% K, 5% R, 1% H, 1% D, 7% E, 14% Q, 4% S, 1% A, 2% G, 1% M
RNA exit channel
RR 173 – 78% R, 2% D, 3% E, 1% N, 5% Q, 5% S, 2% A, 1% T, 2% V
RNA exit channel
VV 174 – 3% K, 3% R, 7% H, 4% D, 24% N, 3% Q, 10% S, 7% A, 1% G, 15% T, 1% I, 1% L, 20% V GG 175 – 5% H, 5% D, 2% E, 4% N, 2% Q, 18% S, 1% A, 55% G, 3% T, 3% L, 1% V- HH 176 – 3% K, 2% R, 17% H, 10% D, 6% E, 1% N, 10% Q, 4% S, 9% A, 2% G, 6% M, 4% T, 6% Y, 5% F, 2% I, 7% L, 2% V, 2% P VV 177 – 1% K, 14% R, 18% H, 2% D, 4% E, 2% N, 1% Q, 4% S, 5% A, 20% T, 1% F, 3% I, 7% L, 16% V YY 178 – 1% K, 6% R, 19% H, 1% M, 65% Y, 4% F, 3% V KK 179 – 76% K, 13% R, 5% Q, 6% S
RNA exit channel
KK 180 – 38% K, 34% R, 8% H, 1% E, 1% G, 1% M, 5% T, 3% W, 2% I, 1% L, 6% V 180
AA 181 – 10% K, 9% R, 1% H, 7% E, 4% N, 2% Q, 4% S, 45% A, 1% C, 1% M, 1% T, 1% Y, 6% I, 4% L, 3% V FF 182 – 1% K, 3% H, 1% S, 3% A, 1% M, 2% T, 40% Y, 32% F, 1% I, 16% V MM 183 – 1% K, 16% A, 1% G, 47% M, 3% Y, 30% L, 2% V QQ 184 – 8% K, 11% R, 1% H, 16% E, 1% N, 21% Q, 5% S, 4% A, 1% G, 7% M, 7% T, 3% Y, 4% I, 6% L, 3% V VV 185 – 12% K, 12% R, 10% H, 1% E, 1% N, 1% Q, 2% S, 36% A, 1% T, 5% Y, 2% L, 16% V- VV 186 – 1% K, 2% R, 5% H, 4% N, 3% Q, 2% S, 7% A, 3% M, 4% T, 4% W, 8% I, 4% L, 49% V, 3% P EE 187 – 1% K, 1% R, 57% E, 1% Q, 18% A, 10% M, 3% T, 1% I, 5% L, 2% V AA 188 – 12% K, 15% R, 5% D, 8% E, 1% N, 8% Q, 10% S, 28% A, 7% G, 2% T, 3% V DD 189 – 15% K, 14% R, 17% H, 15% D, 5% E, 4% N, 4% Q, 9% S, 7% A, 3% G, 1% F, 3% L, 1% V MM 190 – 7% K, 4% R, 3% H, 3% D, 2% E, 1% N, 1% S, 5% A, 50% M, 2% T, 2% Y, 4% I, 11% L, 4% V- LL 191 – 5% K, 8% D, 10% E, 4% N, 6% Q, 1% S, 2% A, 19% G, 3% M, 10% I, 28% L, 3% V SS 192 – 1% R, 21% D, 27% E, 2% N, 2% Q, 5% S, 5% A, 3% G, 1% T, 1% Y, 4% F, 12% I, 3% L, 11% V KK 193 – 25% K, 7% R, 9% D, 2% E, 11% Q, 2% S, 39% A, 2% T, 2% L, 2% V GG 194 – 11% K, 2% R, 2% D, 2% E, 13% N, 5% S, 62% G, 2% V, 2% P LL 195 – 4% K, 6% D, 46% E, 2% N, 19% Q, 6% M, 2% I, 15% L, 2% V- LL 196 – 2% D, 2% E, 2% S, 2% G, 6% M, 6% I, 76% L, 6% V GG 197 – 19% K, 4% H, 13% D, 2% E, 15% N, 9% Q, 2% S, 8% A, 19% G, 6% T, 2% Y, 2% V GG 198 – 7% D, 11% E, 2% Q, 16% S, 4% A, 36% G, 18% T, 4% V, 2% P EE 199 – 14% D, 64% E, 14% Q, 7% T AA 200 – 7% K, 3% H, 6% D, 27% E, 4% N, 4% Q, 7% S, 20% A, 5% G, 9% T, 3% V, 4% P 200
WW 201 – 1% R, 2% H, 1% D, 3% E, 4% Q, 1% A, 1% G, 3% T, 74% W, 3% F, 1% I, 3% L, 1% V, 1% P SS 202 – 2% K, 1% R, 1% H, 15% D, 19% E, 4% N, 8% Q, 11% S, 9% A, 4% G, 9% T, 1% Y, 3% F, 1% I, 3% L, 5% V, 2% P SS 203 – 7% K, 10% R, 3% H, 10% D, 14% E, 2% N, 1% Q, 16% S, 9% A, 1% C, 14% G, 5% T, 1% Y, 1% I, 1% L, 3% P WW 204 – 3% R, 1% Q, 90% W, 3% F, 1% I, 2% L
Surface Loop
HH 205 – 3% K, 2% H, 18% D, 7% E, 4% N, 4% Q, 32% S, 1% A, 4% G, 17% T, 1% I, 6% P
Surface Loop
- KK 206 – 14% K, 11% R, 1% H, 7% D, 7% E, 12% N, 6% Q, 3% S, 14% A, 2% G, 10% T, 1% I, 1% L, 4% V, 5% P
Surface Loop
EE 207 – 6% K, 7% R, 29% D, 20% E, 4% N, 4% Q, 3% S, 7% A, 3% G, 12% T, 1% Y, 2% I, 1% L
Surface Loop
DD 208 – 1% K, 2% R, 36% D, 23% E, 2% N, 4% Q, 2% S, 2% A, 1% G, 2% M, 2% T, 7% I, 2% L, 13% V SS 209 – 6% K, 35% R, 2% H, 1% E, 2% N, 3% Q, 6% S, 9% A, 3% C, 5% G, 5% M, 12% T, 1% Y, 1% I, 5% L, 3% V II 210 – 5% H, 2% E, 7% A, 1% C, 8% M, 4% T, 6% Y, 11% F, 22% I, 19% L, 13% V- HH 211 – 7% K, 4% R, 46% H, 3% N, 11% Q, 2% S, 5% A, 1% C, 2% T, 2% Y, 2% I, 13% L, 1% V VV 212 – 1% A, 1% C, 7% M, 6% T, 5% F, 13% I, 8% L, 58% V GG 213 – 2% A, 98% G VV 214 – 2% E, 2% N, 1% Q, 3% S, 11% A, 1% C, 7% M, 5% T, 1% Y, 2% F, 30% I, 15% L, 19% V RR 215 – 57% K, 28% R, 3% H, 2% Q, 3% S, 2% A, 2% M, 1% T, 2% V- CC 216 – 2% A, 13% C, 24% M, 2% I, 56% L, 2% V II 217 – 3% M, 37% I, 47% L, 13% V EE 218 – 1% H, 16% D, 77% E, 2% N, 3% S, 1% Y MM 219 – 1% K, 5% A, 1% C, 8% M, 2% T, 2% F, 27% I, 51% L, 3% V LL 220 – 4% A, 5% C, 5% M, 5% T, 1% Y, 9% F, 5% I, 53% L, 12% V 220
II 221 – 2% Q, 2% S, 6% A, 1% C, 6% M, 1% T, 68% I, 5% L, 8% V EE 222 – 6% K, 1% R, 1% D, 55% E, 3% N, 16% Q, 3% S, 8% A, 2% G, 2% T, 1% L, 1% V SS 223 – 1% R, 1% N, 1% Q, 57% S, 22% A, 1% C, 4% G, 9% T, 3% V TT 224 – 11% S, 1% A, 1% C, 77% T, 7% I, 2% V GG 225 – 4% E, 2% N, 14% Q, 1% A, 79% G- MM 226 – 4% M, 1% T, 4% Y, 3% F, 6% I, 81% L, 1% V VV 227 – 3% A, 3% G, 15% F, 22% I, 7% L, 49% V SS 228 – 2% K, 3% R, 4% H, 68% E, 8% Q, 1% S, 1% A, 1% C, 2% T, 9% V LL 229 – 5% K, 6% R, 1% A, 7% M, 3% T, 2% Y, 3% F, 15% I, 40% L, 17% V HH 230 – 13% K, 5% R, 6% H, 5% D, 19% E, 3% N, 9% Q, 5% S, 1% A, 2% G, 10% T, 1% Y, 3% F, 1% I, 15% V
Begin insertion
- RR 231 – 1% K, 48% R, 7% H, 2% D, 3% E, 4% N, 3% Q, 4% S, 2% A, 2% M, 14% T, 1% I, 2% L, 5% V, 1% P QQ 232 – 3% K, 6% R, 4% H, 4% D, 17% E, 9% N, 12% Q, 1% S, 1% G, 3% M, 4% T, 3% Y, 7% I, 3% L, 17% V, 4% P NN 233 – 7% K, 3% R, 13% H, 1% D, 2% E, 20% N, 7% Q, 10% S, 6% A, 8% G, 2% M, 6% T, 2% Y, 5% F, 1% L, 4% V, 1% P
Intercalating loop
AA 234 – 10% K, 4% R, 2% H, 3% D, 9% E, 1% N, 5% Q, 9% S, 34% A, 4% G, 2% M, 3% T, 1% Y, 4% V, 6% P
Intercalating loop
GG 235 – 2% K, 7% H, 2% Q, 3% A, 81% G, 2% T, 2% F, 2% L
Intercalating loop
- VV 236 – 3% K, 2% R, 3% H, 10% D, 2% E, 29% N, 1% Q, 3% S, 3% A, 23% G, 1% M, 3% T, 8% I, 7% V
Intercalating loop
VV 237 – 29% K, 6% R, 1% H, 1% D, 1% E, 1% N, 1% Q, 3% S, 20% A, 5% G, 2% T, 4% I, 2% L, 16% V, 6% P
Intercalating loop
GG 238 – 32% K, 4% R, 3% H, 8% D, 5% E, 9% N, 3% Q, 4% S, 8% A, 12% G, 4% T, 2% Y, 4% F, 1% V
Intercalating loop
QQ 239 – 19% K, 14% R, 2% H, 15% D, 3% E, 6% N, 6% Q, 7% S, 7% A, 3% G, 2% M, 1% T, 1% Y, 13% L
Intercalating loop
DD 240 – 1% K, 2% R, 4% H, 47% D, 7% E, 1% Q, 10% S, 5% A, 1% G, 1% M, 16% T, 1% I, 2% V, 1% P 240
SS 241 – 2% K, 8% R, 7% H, 6% E, 4% N, 7% Q, 9% S, 5% A, 4% C, 16% G, 3% M, 2% T, 7% I, 8% L, 8% V, 2% P EE 242 – 9% K, 1% H, 1% D, 35% E, 3% N, 10% Q, 2% S, 2% A, 2% M, 10% T, 3% Y, 7% I, 7% L, 7% V TT 243 – 1% R, 2% H, 4% E, 4% N, 1% Q, 3% S, 6% A, 1% C, 5% M, 10% T, 29% Y, 6% F, 5% I, 9% L, 13% V II 244 – 26% I, 23% L, 51% V EE 245 – 12% K, 7% R, 10% H, 12% E, 1% N, 9% Q, 6% S, 4% A, 1% C, 10% T, 7% Y, 2% F, 3% I, 2% L, 12% V- LL 246 – 20% A, 6% G, 3% M, 1% F, 8% I, 46% L, 1% V, 14% P AA 247 – 4% K, 1% R, 6% H, 1% D, 2% E, 4% N, 15% S, 19% A, 41% T, 6% L PP 248 – 8% K, 2% R, 14% D, 16% E, 1% N, 11% Q, 2% S, 4% A, 1% G, 1% L, 39% P EE 249 – 8% K, 4% R, 2% D, 48% E, 7% Q, 4% S, 12% A, 2% G, 1% T, 2% W, 2% F, 1% I, 1% L, 1% V, 4% P YY 250 – 1% H, 4% A, 20% T, 23% W, 21% Y, 12% F, 3% I, 7% L, 7% V- AA 251 – 3% K, 2% R, 2% D, 4% S, 28% A, 9% M, 1% T, 5% I, 26% L, 20% V EE 252 – 11% K, 3% R, 33% D, 36% E, 4% N, 3% Q, 8% A, 2% T AA 253 – 22% K, 3% R, 1% E, 4% Q, 10% A, 1% G, 2% M, 1% T, 40% W, 8% I, 4% L, 3% V II 254 – 3% A, 8% M, 4% W, 30% I, 49% L, 6% V AA 255 – 5% K, 5% D, 10% E, 13% N, 3% Q, 21% S, 23% A, 6% C, 3% G, 7% T, 1% L, 1% V- TT 256 – 30% K, 6% R, 1% H, 7% D, 9% E, 7% N, 9% Q, 7% S, 3% A, 2% G, 1% M, 16% T, 1% I RR 257 – 7% K, 55% R, 1% H, 11% E, 4% N, 2% S, 7% A, 1% G, 2% Y, 2% I, 5% L, 2% V
RNA exit channel
AA 258 – 6% H, 6% D, 4% E, 24% N, 4% S, 45% A, 3% G, 1% M, 4% T, 2% L GG 259 – 4% H, 10% D, 7% E, 4% N, 3% Q, 8% S, 9% A, 18% G, 4% M, 3% T, 7% Y, 18% F, 1% I, 2% L AA 260 – 5% K, 19% R, 1% E, 4% N, 5% Q, 27% S, 24% A, 1% G, 2% T, 2% F, 3% I, 1% L, 5% V 260
LL 261 – 2% Q, 1% S, 7% A, 6% C, 2% G, 2% M, 6% T, 4% F, 67% L, 2% V AA 262 – 1% D, 15% E, 2% Q, 9% S, 65% A, 1% G, 2% M, 2% I, 2% V GG 263 – 6% H, 5% D, 6% E, 1% Q, 3% S, 9% A, 41% G, 3% M, 1% Y, 1% F, 3% I, 13% L, 3% V, 4% P II 264 – 1% K, 2% R, 1% N, 1% Q, 1% S, 2% A, 1% C, 15% M, 3% Y, 4% F, 43% I, 20% L, 5% V SS 265 – 1% K, 8% R, 3% H, 9% N, 1% Q, 39% S, 23% A, 8% T, 6% F, 1% V
Refolding loop
- PP 266 – 1% H, 1% Q, 8% T, 4% Y, 2% V, 84% P
Refolding loop
MM 267 – 1% K, 12% R, 2% H, 5% E, 2% Q, 3% S, 3% A, 24% M, 1% T, 2% Y, 1% F, 11% I, 3% L, 29% V
Refolding loop
FF 268 – 3% R, 19% H, 5% N, 2% Q, 1% A, 1% M, 1% T, 3% W, 39% Y, 21% F, 4% L
Refolding loop
QQ 269 – 8% E, 48% Q, 1% S, 3% A, 5% C, 11% M, 1% Y, 22% L PP 270 – 100% P- CC 271 – 1% S, 37% C, 37% M, 24% T VV 272 – 21% I, 9% L, 70% V VV 273 – 15% I, 2% L, 83% V PP 274 – 3% K, 8% Q, 1% S, 1% I, 87% P PP 275 – 100% P- KK 276 – 57% K, 33% R, 3% N, 1% S, 2% A, 1% I, 2% L, 1% V PP 277 – 3% K, 3% R, 12% D, 9% E, 1% N, 2% Q, 1% A, 69% P WW 278 – 100% W TT 279 – 4% K, 1% R, 2% D, 1% E, 4% N, 7% S, 1% C, 66% T, 1% I, 13% V GG 280 – 3% K, 5% R, 3% H, 2% D, 6% E, 7% N, 23% S, 2% A, 29% G, 19% T 280
II 281 – 1% R, 1% H, 1% N, 3% S, 3% A, 6% M, 4% T, 3% W, 2% Y, 2% F, 13% I, 9% L, 16% V, 35% P
Surface Loop
TT 282 – 10% K, 11% R, 5% H, 2% D, 3% E, 3% Q, 4% S, 3% M, 15% T, 5% Y, 14% F, 6% I, 17% V
Surface Loop
GG 283 – 2% K, 3% R, 20% D, 3% E, 4% N, 2% Q, 3% S, 4% A, 59% G
Surface Loop; Begin insertion
GG 284 – 99% G GG 285 – 2% A, 97% G- YY 286 – 99% Y WW 287 – 7% H, 61% W, 14% Y, 2% F, 3% I, 13% L AA 288 – 21% S, 37% A, 12% G, 26% T, 3% F NN 289 – 26% K, 4% R, 8% D, 8% E, 16% N, 2% Q, 8% S, 12% A, 5% G, 5% T, 2% V, 2% P GG 290 – 9% R, 5% H, 1% D, 3% E, 4% N, 1% Q, 5% S, 12% A, 49% G, 1% M, 1% T, 2% I, 5% L- RR 291 – 7% K, 48% R, 3% Q, 3% A, 5% G, 4% T, 4% F, 9% I, 11% V, 3% P
RNA exit channel
RR 292 – 35% K, 41% R, 2% N, 6% S, 4% A, 6% G, 3% Y
RNA exit channel
PP 293 – 1% K, 11% R, 1% H, 3% N, 2% A, 1% G, 1% T, 1% Y, 1% F, 2% I, 3% L, 72% P LL 294 – 2% Q, 3% S, 2% M, 9% T, 2% F, 7% I, 56% L, 15% V AA 295 – 12% K, 15% R, 3% D, 4% N, 5% Q, 12% S, 12% A, 2% M, 11% T, 3% L, 19% P- LL 296 – 8% M, 22% F, 68% L VV 297 – 2% M, 2% F, 42% I, 4% L, 50% V RR 298 – 31% K, 68% R TT 299 – 6% A, 6% G, 53% T, 5% I, 5% L, 21% V HH 300 – 6% K, 31% R, 26% H, 2% E, 2% N, 3% S, 3% A, 14% G, 1% M, 2% Y, 1% F, 1% L, 8% P 300
SS 301 – 2% R, 3% H, 34% N, 35% S, 3% A, 4% G, 14% T, 3% L KK 302 – 61% K, 21% R, 2% D, 4% Q, 3% A, 3% L, 2% V KK 303 – 28% K, 13% R, 7% E, 5% N, 8% Q, 5% S, 25% A, 2% T, 3% V, 2% P AA 304 – 3% R, 6% H, 2% S, 41% A, 8% G, 35% Y, 2% F, 3% V LL 305 – 9% K, 3% R, 3% N, 2% M, 2% I, 73% L, 3% V- MM 306 – 14% K, 14% R, 2% H, 8% D, 28% E, 3% N, 4% Q, 7% S, 8% A, 9% M, 2% T RR 307 – 2% K, 53% R, 5% D, 27% E, 2% N, 4% A, 3% L, 3% V YY 308 – 54% Y, 43% L EE 309 – 9% K, 27% R, 5% D, 19% E, 11% N, 4% Q, 3% S, 13% A, 6% G DD 310 – 2% H, 47% D, 13% E, 13% N, 7% Q, 6% S, 2% A, 4% G, 2% Y, 3% L- VV 311 – 5% R, 4% H, 9% A, 3% M, 4% T, 2% I, 6% L, 62% V YY 312 – 10% H, 50% D, 9% E, 3% N, 6% S, 17% Y, 2% F MM 313 – 69% M, 3% I, 27% L PP 314 – 2% K, 2% D, 2% E, 16% S, 12% T, 63% P EE 315 – 4% K, 6% R, 2% D, 50% E, 6% N, 5% Q, 4% A, 2% G, 4% M, 6% I, 5% V, 5% P- VV 316 – 3% I, 96% V YY 317 – 3% R, 5% M, 76% Y, 5% F, 3% I, 6% L KK 318 – 38% K, 2% R, 3% H, 13% D, 18% E, 8% Q, 7% S, 8% A, 2% G AA 319 – 12% S, 83% A, 2% G II 320 – 22% I, 14% L, 63% V 320
NN 321 – 99% N II 322 – 3% R, 2% H, 4% S, 36% A, 6% T, 2% Y, 29% I, 17% L, 2% V AA 323 – 43% A, 11% M, 34% I, 10% L, 2% V QQ 324 – 100% Q NN 325 – 10% R, 2% H, 7% D, 16% E, 36% N, 5% Q, 10% S, 15% A- TT 326 – 8% S, 91% T AA 327 – 60% A, 39% P WW 328 – 98% W, 2% F KK 329 – 37% K, 16% R, 10% Q, 8% S, 23% A, 4% T II 330 – 72% I, 28% V- NN 331 – 3% E, 97% N KK 332 – 36% K, 5% R, 2% H, 3% D, 2% E, 4% Q, 11% S, 5% A, 2% G, 19% T, 3% L, 2% V, 6% P KK 333 – 43% K, 22% R, 2% D, 7% E, 11% Q, 2% S, 2% A, 9% P VV 334 – 4% T, 6% I, 88% V LL 335 – 2% Y, 2% F, 93% L- AA 336 – 4% K, 27% D, 34% E, 4% N, 25% A, 3% T VV 337 – 2% A, 2% I, 96% V AA 338 – 40% A, 23% M, 4% I, 6% L, 28% V NN 339 – 16% K, 17% R, 11% E, 39% N, 10% Q, 4% T VV 340 – 4% K, 2% R, 2% H, 3% D, 33% E, 3% N, 8% Q, 3% S, 26% A, 4% M, 9% T, 4% V 340
II 341 – 4% A, 23% I, 44% L, 28% V TT 342 – 3% E, 2% S, 6% A, 12% M, 11% T, 28% W, 6% Y, 2% F, 8% I, 9% L, 12% V KK 343 – 12% K, 2% R, 17% D, 15% E, 17% N, 11% Q, 9% S, 6% A, 5% G, 4% T WW 344 – 5% R, 3% E, 7% N, 2% Q, 5% S, 8% A, 3% G, 2% M, 8% T, 50% W, 5% L KK 345 – 26% K, 3% R, 3% D, 8% E, 4% N, 9% Q, 2% S, 4% A, 35% G, 2% T, 4% P- HH 346 – 2% K, 5% R, 36% H, 2% E, 52% N, 2% Y, 2% F CC 347 – 5% N, 19% S, 6% A, 19% C, 11% G, 7% T, 2% L, 22% V, 4% P PP 348 – 3% D, 11% E, 2% N, 13% G, 13% T, 2% I, 3% V, 49% P VV 349 – 2% M, 36% I, 19% L, 40% V EE 350 – 16% K, 11% D, 11% E, 8% S, 41% A, 11% G- DD 351 – 15% K, 34% D, 6% E, 2% N, 4% S, 4% C, 34% G II 352 – 6% M, 7% W, 2% Y, 17% F, 26% I, 27% L, 15% V PP 353 – 3% A, 2% V, 95% P AA 354 – 6% R, 2% H, 3% E, 11% Q, 23% S, 18% A, 3% C, 3% G, 10% T, 3% L, 14% P II 355 – 2% K, 17% R, 2% H, 3% Q, 5% S, 24% A, 2% G, 12% M, 5% T, 2% F, 10% I, 12% L, 2% V, 2% P- EE 356 – 2% K, 31% D, 42% E, 5% N, 2% Q, 7% A, 3% I, 3% L, 3% V RR 357 – 20% K, 20% R, 16% D, 5% E, 1% N, 2% Q, 2% A, 12% G, 3% T, 1% I, 6% L, 4% V, 7% P EE 358 – 3% K, 2% R, 5% D, 26% E, 7% Q, 1% S, 6% A, 4% G, 4% M, 2% Y, 1% F, 11% I, 22% L, 3% V, 2% P EE 359 – 2% K, 1% R, 10% D, 46% E, 4% Q, 10% A, 2% I, 1% V, 24% P LL 360 – 5% K, 1% R, 1% H, 1% Q, 1% S, 1% A, 7% M, 1% F, 3% I, 68% L, 3% V, 6% P 360
PP 361 – 100% P MM 362 – 2% D, 15% E, 5% Q, 3% S, 11% A, 3% G, 3% M, 9% T, 6% I, 9% L, 17% V, 17% P KK 363 – 59% K, 27% R, 3% Q, 6% L, 3% V PP 364 – 3% Y, 3% L, 89% P EE 365 – 1% R, 16% H, 20% D, 23% E, 2% Q, 5% S, 6% A, 4% G, 2% M, 1% T, 2% W, 2% Y, 4% F, 1% I, 4% L, 5% V- DD 366 – 55% D, 4% E, 5% N, 1% Q, 1% S, 1% A, 13% G, 9% W, 5% F, 5% L II 367 – 1% E, 1% N, 1% Q, 1% S, 3% A, 14% M, 1% T, 1% F, 58% I, 18% L DD 368 – 57% D, 17% E, 3% N, 2% S, 5% A, 6% G, 4% V, 4% P
Begin insertion
MM 369 – 2% H, 7% D, 33% E, 4% A, 43% T, 2% Y, 2% V, 4% P NN 370 – 3% H, 17% D, 2% E, 49% N, 13% Q, 3% S, 12% T- PP 371 – 3% K, 2% R, 4% D, 50% E, 2% Q, 3% A, 3% M, 5% L, 4% V, 25% P EE 372 – 2% K, 2% R, 12% D, 53% E, 2% Q, 9% A, 2% G, 3% T, 3% I, 2% L, 7% V AA 373 – 21% E, 6% Q, 12% S, 42% A, 6% L, 10% V LL 374 – 5% K, 15% R, 18% F, 2% I, 58% L TT 375 – 70% K, 8% R, 2% N, 3% Q, 2% S, 3% A, 6% T, 4% L- AA 376 – 6% K, 4% R, 2% H, 18% E, 3% N, 5% Q, 4% S, 49% A, 3% T, 2% L, 4% V WW 377 – 4% H, 84% W, 10% Y KK 378 – 82% K, 18% R RR 379 – 56% K, 23% R, 2% Q, 4% S, 5% A, 2% W, 6% I AA 380 – 10% K, 6% D, 32% E, 10% Q, 5% S, 31% A, 2% L, 2% V 380
AA 381 – 2% K, 8% R, 73% A, 3% C, 3% M, 7% T, 3% L AA 382 – 2% K, 2% R, 5% H, 18% S, 47% A, 11% T, 5% F, 2% I, 9% V AA 383 – 13% K, 6% R, 9% D, 9% E, 4% Q, 24% A, 16% G, 8% T, 3% L, 3% V, 3% P VV 384 – 2% R, 2% H, 6% A, 10% T, 3% Y, 3% F, 25% I, 2% L, 45% V YY 385 – 24% H, 73% Y- RR 386 – 6% K, 55% R, 11% E, 2% N, 5% Q, 2% S, 3% A, 2% M, 6% T, 2% L, 3% V KK 387 – 34% K, 18% R, 2% H, 2% D, 12% E, 2% N, 3% Q, 3% S, 15% A, 3% G, 2% M, 2% F, 3% L
NTP channel
DD 388 – 2% R, 28% D, 29% E, 37% N, 2% M KK 389 – 34% K, 11% R, 3% D, 2% E, 3% N, 3% S, 27% A, 2% T, 2% I, 9% L AA 390 – 8% K, 18% R, 2% E, 2% Q, 17% S, 48% A, 3% T, 2% V- RR 391 – 59% R, 4% N, 5% S, 5% A, 5% M, 6% I, 14% L
NTP channel
KK 392 – 16% K, 8% R, 8% Q, 5% S, 5% A, 2% G, 5% T, 3% F, 8% I, 4% L, 36% V SS 393 – 83% S, 13% G RR 394 – 25% K, 53% R, 2% D, 8% Q, 2% S, 5% L RR 395 – 91% R, 6% A
NTP channel
- II 396 – 3% R, 5% A, 11% M, 3% Y, 16% I, 55% L, 4% V SS 397 – 16% R, 11% Q, 46% S, 13% A, 5% G, 5% L LL 398 – 2% Q, 10% A, 3% C, 16% M, 4% T, 11% Y, 19% F, 2% I, 25% L, 8% V EE 399 – 3% R, 2% D, 49% E, 4% N, 10% S, 10% A, 2% G, 3% T, 2% I, 11% L, 2% V FF 400 – 11% K, 9% R, 6% Q, 7% S, 6% G, 10% M, 5% T, 41% F, 4% L 400
MM 401 – 7% K, 2% H, 6% N, 6% S, 10% A, 17% M, 27% T, 17% I, 2% L, 6% V LL 402 – 18% I, 61% L, 17% V EE 403 – 3% K, 3% R, 2% H, 6% D, 27% E, 5% N, 5% Q, 6% S, 16% A, 16% G, 2% M, 2% T, 5% W QQ 404 – 50% Q, 4% M, 8% T, 13% I, 11% L, 14% V AA 405 – 97% A, 3% G- NN 406 – 6% K, 8% R, 6% D, 25% E, 41% N, 5% Q, 3% S, 3% A, 2% G, 2% T KK 407 – 65% K, 22% R, 7% E, 2% M, 2% T FF 408 – 15% Y, 84% F AA 409 – 16% K, 5% R, 9% E, 3% N, 18% S, 48% A NN 410 – 10% K, 4% H, 28% D, 15% E, 10% N, 16% Q, 2% S, 2% A, 9% G, 5% P- HH 411 – 4% K, 7% H, 3% D, 22% E, 33% Y, 30% F KK 412 – 23% K, 6% R, 11% D, 40% E, 2% Q, 3% S, 3% A, 11% P AA 413 – 9% K, 11% R, 9% E, 4% S, 65% A II 414 – 12% F, 83% I, 4% L WW 415 – 31% W, 59% Y, 10% F- FF 416 – 4% M, 4% Y, 92% F PP 417 – 2% V, 98% P YY 418 – 43% H, 4% C, 4% M, 47% Y NN 419 – 62% N, 24% Q, 7% S, 6% T MM 420 – 34% M, 5% F, 58% L, 2% V 420
DD 421 – 100% D
DX2GR
WW 422 – 53% W, 45% F
DX2GR
RR 423 – 100% R
DX2GR
GG 424 – 99% G
DX2GR
RR 425 – 100% R
DX2GR
- VV 426 – 12% A, 2% C, 16% I, 4% L, 65% V YY 427 – 100% Y AA 428 – 8% S, 68% A, 22% P VV 429 – 4% A, 2% C, 2% T, 27% I, 17% L, 47% V SS 430 – 8% S, 10% T, 81% P- MM 431 – 2% K, 7% H, 4% Q, 16% S, 11% A, 23% M, 7% T, 5% Y, 11% F, 5% L, 8% V FF 432 – 59% F, 39% L NN 433 – 76% N, 16% S, 7% T PP 434 – 3% F, 97% P QQ 435 – 100% Q- GG 436 – 5% S, 93% G NN 437 – 22% D, 50% N, 2% Q, 19% S, 3% A, 2% T DD 438 – 100% D MM 439 – 2% H, 4% Q, 6% A, 35% M, 4% Y, 4% F, 6% I, 29% L, 8% V TT 440 – 4% D, 5% N, 14% Q, 5% S, 16% A, 2% G, 4% M, 45% T, 5% V 440
KK 441 – 91% K, 6% R, 3% H GG 442 – 5% S, 17% A, 78% G LL 443 – 8% I, 88% L, 2% V LL 444 – 2% I, 97% L TT 445 – 3% K, 10% R, 2% H, 2% E, 20% Q, 2% C, 7% M, 43% T, 2% I, 7% L, 3% V- LL 446 – 21% A, 56% F, 23% L AA 447 – 20% S, 80% A KK 448 – 27% K, 7% H, 14% D, 12% E, 16% N, 7% Q, 6% S, 5% I, 5% V GG 449 – 2% K, 3% S, 18% A, 71% G, 2% V, 3% P KK 450 – 46% K, 2% D, 21% E, 2% A, 2% G, 18% V, 7% P- PP 451 – 3% R, 4% E, 6% A, 85% P II 452 – 4% C, 55% I, 24% L, 16% V
Surface Loop
GG 453 – 2% K, 4% H, 2% D, 3% N, 80% G, 4% T
Surface Loop; Begin insertion
KK 454 – 14% K, 2% R, 2% D, 35% E, 3% N, 4% Q, 6% S, 17% A, 2% M, 2% T, 7% L, 2% V, 3% P
Surface Loop
EE 455 – 2% K, 2% R, 2% H, 28% D, 52% E, 3% Q, 3% S, 4% T
Surface Loop
- GG 456 – 6% D, 2% N, 7% A, 83% G YY 457 – 3% K, 5% R, 2% E, 24% A, 2% G, 3% M, 6% W, 2% Y, 20% F, 21% I, 9% L, 2% V YY 458 – 25% K, 6% R, 7% D, 16% E, 4% N, 4% Q, 4% G, 26% Y, 4% F WW 459 – 96% W, 2% L LL 460 – 8% F, 92% L 460
KK 461 – 37% K, 4% R, 38% A, 16% M, 5% L II 462 – 6% M, 73% I, 20% V HH 463 – 97% H GG 464 – 89% G, 3% L, 5% V AA 465 – 98% A- NN 466 – 91% N, 8% G CC 467 – 4% S, 40% C, 28% T, 15% L, 12% V AA 468 – 68% A, 8% W, 9% Y, 14% F GG 469 – 100% G VV 470 – 3% H, 2% E, 2% M, 13% Y, 5% F, 6% I, 2% L, 64% V- DD 471 – 100% D
NTP channel
KK 472 – 100% K
NTP channel
VV 473 – 2% D, 3% E, 7% A, 4% C, 2% W, 80% V PP 474 – 12% D, 40% S, 2% G, 12% T, 33% P FF 475 – 6% M, 2% Y, 69% F, 2% I, 21% L
Surface Loop
- PP 476 – 27% D, 35% E, 2% N, 3% S, 11% A, 2% G, 16% P
Surface Loop
EE 477 – 20% D, 65% E, 8% Q, 2% G, 2% V
Surface Loop
RR 478 – 99% R II 479 – 14% K, 2% R, 3% Q, 39% I, 6% L, 34% V KK 480 – 31% K, 2% R, 3% D, 5% E, 4% N, 35% Q, 2% S, 15% A, 2% T 480
FF 481 – 82% W, 18% F II 482 – 6% T, 22% I, 71% V EE 483 – 11% K, 12% R, 5% H, 5% D, 38% E, 3% N, 4% Q, 3% M, 3% Y, 16% L EE 484 – 3% K, 58% D, 25% E, 2% Q, 3% S, 6% A NN 485 – 22% H, 76% N- HH 486 – 20% H, 54% E, 7% Q, 5% S, 5% T, 2% L, 4% V EE 487 – 3% K, 6% R, 23% D, 37% E, 2% N, 3% Q, 4% S, 15% A, 2% G, 2% T, 2% V NN 488 – 3% K, 5% R, 5% H, 2% D, 20% E, 22% N, 8% Q, 2% A, 4% C, 8% M, 3% T, 15% L, 3% V II 489 – 99% I MM 490 – 2% R, 18% M, 2% T, 12% I, 60% L, 3% V- AA 491 – 2% K, 13% R, 9% D, 17% E, 3% N, 6% Q, 7% S, 42% A CC 492 – 32% S, 8% A, 32% C, 4% T, 12% I, 13% V AA 493 – 2% S, 98% A KK 494 – 20% K, 15% R, 3% H, 2% D, 19% E, 3% N, 6% Q, 3% S, 18% A, 3% T, 7% L SS 495 – 64% D, 19% N, 3% Q, 8% S, 5% A- PP 496 – 100% P LL 497 – 6% M, 13% Y, 7% F, 4% I, 65% L EE 498 – 34% D, 10% E, 15% N, 7% Q, 4% S, 5% A, 17% G, 4% T, 3% V NN 499 – 7% H, 5% D, 5% E, 46% N, 4% Q, 3% S, 4% C, 7% G, 2% T, 8% Y, 7% F TT 500 – 27% R, 3% D, 3% E, 7% S, 36% T, 22% L 500
WW 501 – 3% D, 17% E, 8% G, 2% M, 44% W, 2% Y, 22% F WW 502 – 100% W AA 503 – 2% Q, 4% S, 36% A, 6% C, 5% G, 22% M, 23% T, 2% L EE 504 – 14% K, 14% D, 39% E, 2% N, 10% Q, 9% S, 2% A, 2% G, 6% T
Surface Loop
QQ 505 – 26% Q, 34% A, 23% M, 9% I, 5% L, 3% V
Surface Loop; Begin insertion
- DD 506 – 95% D, 5% E
Surface Loop
SS 507 – 21% K, 72% S, 3% C
Surface Loop
PP 508 – 3% K, 95% P FF 509 – 2% C, 25% W, 2% Y, 68% F, 2% L CC 510 – 29% Q, 2% S, 59% C, 3% G, 3% M, 3% V- FF 511 – 9% A, 90% F LL 512 – 100% L AA 513 – 95% A, 2% G, 3% T FF 514 – 11% A, 4% W, 84% F CC 515 – 3% A, 97% C- FF 516 – 2% Y, 90% F, 2% I, 4% L EE 517 – 2% D, 98% E YY 518 – 56% W, 40% Y, 2% F AA 519 – 5% K, 3% H, 2% D, 7% E, 7% Q, 64% A, 7% L GG 520 – 2% K, 2% R, 2% D, 5% N, 7% Q, 10% A, 67% G, 3% M
Surface Loop; Begin insertion
520
VV 521 – 4% A, 9% W, 19% Y, 15% F, 5% L, 47% V
Surface Loop
QQ 522 – 28% K, 8% R, 3% H, 3% E, 6% Q, 3% S, 4% C, 8% M, 6% T, 2% Y, 6% I, 4% L, 16% V
Surface Loop
HH 523 – 8% K, 16% R, 14% H, 2% D, 18% E, 4% N, 3% Q, 2% S, 13% A, 2% M, 5% T, 2% I, 6% L, 4% V
Surface Loop
HH 524 – 2% K, 33% H, 13% D, 14% E, 12% N, 6% Q, 2% S, 2% A, 8% T, 2% F, 2% V
Surface Loop
GG 525 – 88% G, 10% P
Surface Loop
- LL 526 – 4% K, 2% R, 7% D, 26% E, 5% A, 2% M, 2% T, 7% Y, 6% F, 2% I, 24% L, 2% V, 8% P
Surface Loop
SS 527 – 2% K, 9% D, 8% E, 14% N, 2% Q, 26% S, 11% A, 21% G, 2% T, 4% L YY 528 – 15% H, 10% W, 44% Y, 31% F NN 529 – 5% K, 7% R, 12% E, 12% N, 2% S, 2% A, 2% M, 6% L, 49% V CC 530 – 70% S, 25% C, 4% T- SS 531 – 6% K, 10% R, 15% H, 34% S, 19% A, 2% C, 9% G, 4% T LL 532 – 16% I, 82% L, 2% V
Motif A
PP 533 – 4% A, 3% V, 91% P
Motif A
LL 534 – 45% I, 21% L, 34% V
Motif A
AA 535 – 11% Q, 5% S, 83% A
Motif A
- FF 536 – 2% Q, 24% M, 62% F, 9% L
Motif A
DD 537 – 100% D
Motif A
GG 538 – 100% G
Motif A
SS 539 – 82% S, 17% T
Motif A
CC 540 – 2% N, 98% C
Motif A
540
SS 541 – 28% N, 72% S
Motif A
GG 542 – 100% G
Motif A
II 543 – 2% A, 59% I, 38% L
Motif A
QQ 544 – 100% Q
Motif A
HH 545 – 82% H, 18% N
Motif A
- FF 546 – 6% Y, 94% F
Motif A
SS 547 – 99% S AA 548 – 99% A MM 549 – 2% A, 91% M, 4% I, 3% L LL 550 – 100% L- RR 551 – 6% K, 84% R, 2% Q, 8% L DD 552 – 99% D EE 553 – 5% H, 67% E, 7% S, 3% A, 15% P VV 554 – 3% K, 16% R, 6% T, 24% I, 50% V GG 555 – 98% G- GG 556 – 4% A, 96% G RR 557 – 14% K, 33% R, 7% H, 2% E, 4% Q, 3% S, 32% A, 2% G AA 558 – 99% A VV 559 – 5% T, 95% V NN 560 – 99% N 560
LL 561 – 100% L LL 562 – 10% T, 16% I, 40% L, 32% V
Surface Loop
PP 563 – 2% Q, 96% P
Surface Loop; Begin insertion
SS 564 – 2% D, 11% Q, 59% S, 13% A, 9% G, 3% T
Surface Loop
EE 565 – 3% K, 39% D, 32% E, 2% S, 4% A, 5% G, 6% T, 5% P
Surface Loop
- TT 566 – 36% K, 7% R, 2% D, 16% E, 3% Q, 5% S, 19% T, 8% L VV 567 – 2% R, 46% V, 52% P QQ 568 – 2% H, 3% E, 7% N, 63% Q, 9% S, 16% A DD 569 – 100% D II 570 – 91% I, 9% V- YY 571 – 100% Y GG 572 – 12% K, 39% R, 22% Q, 3% S, 7% A, 13% G, 4% T II 573 – 4% K, 7% R, 7% E, 4% Q, 4% A, 6% M, 4% T, 33% I, 28% L, 3% V VV 574 – 99% V AA 575 – 20% S, 71% A, 3% C, 4% M- KK 576 – 9% K, 58% D, 20% E, 4% N, 2% Q, 4% A KK 577 – 34% K, 15% R, 10% E, 5% A, 7% G, 5% I, 4% L, 18% V VV 578 – 7% A, 2% C, 2% I, 4% L, 84% V NN 579 – 3% K, 9% E, 41% N, 4% Q, 3% A, 3% C, 5% M, 2% T, 19% I, 4% L, 6% V EE 580 – 8% K, 4% R, 7% D, 51% E, 2% N, 3% Q, 2% S, 5% A, 1% G, 2% T, 2% I, 5% L, 8% V 580
II 581 – 13% K, 13% R, 6% E, 1% N, 18% Q, 11% A, 3% G, 5% M, 3% T, 1% W, 1% Y, 7% I, 4% L, 13% V LL 582 – 4% A, 1% C, 4% M, 1% T, 5% I, 67% L, 18% V QQ 583 – 25% K, 18% R, 3% H, 3% D, 13% E, 6% N, 11% Q, 1% S, 6% A, 1% G, 1% M, 1% T, 3% Y, 1% I, 5% L, 1% V AA 584 – 11% K, 13% R, 6% H, 7% D, 14% E, 1% N, 11% Q, 15% A, 1% C, 3% G, 1% T, 2% W, 3% Y, 1% I, 2% L, 7% V DD 585 – 1% R, 5% H, 60% D, 5% E, 1% Q, 2% S, 4% A, 2% M, 2% F, 6% I, 11% L- AA 586 – 2% K, 1% R, 1% H, 6% S, 37% A, 2% M, 3% T, 1% F, 1% I, 29% L, 17% V II 587 – 8% K, 2% R, 1% H, 2% D, 14% E, 2% N, 2% Q, 1% S, 14% A, 1% C, 1% G, 4% M, 3% T, 19% I, 6% L, 18% V NN 588 – 3% K, 11% H, 8% D, 10% E, 28% N, 1% Q, 20% S, 4% A, 6% G, 3% M, 3% T, 1% Y, 1% P
Cowcatcher
GG 589 – 3% D, 5% E, 1% N, 1% Q, 1% S, 1% A, 4% C, 81% G, 1% T, 1% I
Cowcatcher
TT 590 – 4% H, 9% D, 3% E, 1% N, 16% S, 1% A, 1% C, 5% G, 1% M, 54% T, 1% L, 3% P
Cowcatcher
- DD 591 – 1% R, 3% H, 26% D, 31% E, 4% Q, 6% S, 8% A, 3% G, 3% M, 1% T, 5% L, 1% V, 6% P
Cowcatcher
NN 592 – 1% K, 51% D, 7% E, 26% N, 5% T, 1% L, 4% V, 4% P
Cowcatcher
EE 593 – 2% K, 2% D, 30% E, 5% Q, 20% S, 4% A, 1% G, 1% M, 16% T, 1% W, 4% Y, 2% I, 2% L, 8% V
Cowcatcher
VV 594 – 1% K, 1% R, 1% E, 1% Q, 6% S, 1% A, 1% C, 1% G, 9% M, 23% T, 3% W, 1% Y, 7% I, 14% L, 28% V
Cowcatcher
VV 595 – 17% K, 2% R, 13% D, 42% E, 3% Q, 2% A, 2% G, 6% T, 3% I, 8% V
Cowcatcher
- TT 596 – 7% K, 3% R, 4% E, 1% Q, 3% A, 4% G, 1% M, 40% T, 4% W, 1% Y, 6% I, 8% L, 17% V
Cowcatcher
VV 597 – 10% K, 4% R, 10% H, 1% D, 8% E, 1% Q, 1% S, 1% A, 4% M, 3% F, 24% I, 10% L, 22% V
Cowcatcher
TT 598 – 4% K, 1% D, 7% E, 1% N, 3% A, 1% G, 49% T, 4% Y, 1% L, 24% V, 1% P
Cowcatcher
DD 599 – 69% D, 3% E, 22% N, 3% C, 1% G, 1% L
Cowcatcher
EE 600 – 49% K, 3% D, 32% E, 1% N, 3% S, 4% A, 1% G, 3% T, 1% V, 1% P
Cowcatcher
600
NN 601 – 39% K, 1% R, 10% H, 19% D, 13% E, 2% N, 2% Q, 1% S, 1% A, 1% G, 8% T, 1% Y
Cowcatcher
TT 602 – 7% R, 7% D, 1% E, 4% N, 11% S, 1% G, 1% M, 67% T, 1% L
Cowcatcher
GG 603 – 9% K, 1% R, 7% D, 4% E, 1% Q, 4% A, 74% G
Cowcatcher
EE 604 – 3% K, 10% D, 78% E, 3% N, 1% Q, 3% S, 1% A, 1% T, 1% V
Cowcatcher
II 605 – 5% K, 4% E, 1% N, 1% S, 1% A, 15% G, 1% M, 4% T, 1% W, 3% F, 59% I, 4% V, 1% P
Cowcatcher
- SS 606 – 13% K, 11% R, 1% H, 3% E, 3% S, 50% T, 1% W, 5% Y, 1% F, 3% I, 3% L, 8% V
Cowcatcher
EE 607 – 4% D, 70% E, 3% Q, 1% S, 11% A, 1% G, 8% T, 1% L, 1% P
Cowcatcher
KK 608 – 25% K, 41% R, 1% E, 1% Q, 13% Y, 8% I, 10% V, 1% P
Cowcatcher
VV 609 – 2% K, 21% R, 1% H, 1% M, 12% T, 2% Y, 1% F, 10% I, 30% L, 15% V, 4% P
Cowcatcher
KK 610 – 32% K, 9% R, 1% E, 9% Q, 1% S, 1% G, 1% M, 5% T, 11% I, 30% V
Cowcatcher
- LL 611 – 4% R, 11% E, 4% Q, 1% S, 1% A, 4% C, 1% M, 1% T, 11% Y, 2% F, 5% I, 53% L, 1% V
Cowcatcher
GG 612 – 2% K, 1% R, 1% D, 1% E, 1% N, 7% S, 85% G, 1% T
Cowcatcher
TT 613 – 6% D, 8% E, 7% S, 1% A, 73% T, 1% L, 3% V
Cowcatcher
KK 614 – 43% K, 24% R, 1% Q, 4% S, 15% A, 1% C, 5% G, 1% W, 3% I, 1% V AA 615 – 3% K, 2% R, 5% D, 13% E, 4% N, 1% Q, 10% S, 13% A, 3% G, 37% T, 2% L, 4% V, 1% P- LL 616 – 1% N, 1% C, 23% M, 2% W, 1% Y, 1% F, 6% I, 63% L, 1% V AA 617 – 3% S, 97% A GG 618 – 6% K, 19% R, 1% H, 9% E, 11% N, 17% Q, 3% S, 18% A, 8% G, 3% M, 1% Y, 2% I, 1% L QQ 619 – 4% K, 6% R, 2% H, 2% E, 42% Q, 10% A, 23% G, 2% M, 4% T, 3% W, 1% L WW 620 – 100% W 620
LL 621 – 1% K, 3% R, 1% H, 1% D, 1% E, 1% N, 1% Q, 1% S, 1% A, 4% G, 5% M, 2% T, 1% F, 3% I, 72% L AA 622 – 6% K, 1% R, 1% H, 7% D, 9% E, 1% N, 5% Q, 2% S, 41% A, 9% G, 4% M, 10% T, 3% P YY 623 – 1% R, 10% H, 1% G, 1% M, 1% W, 46% Y, 40% F GG 624 – 6% K, 1% H, 1% Q, 91% G VV 625 – 13% M, 1% F, 31% I, 1% L, 54% V- TT 626 – 1% K, 18% D, 1% E, 18% N, 13% S, 3% G, 45% T, 1% L
Motif B
RR 627 – 100% R
NTP channel; Motif B
SS 628 – 61% K, 2% D, 3% N, 29% S, 5% G
Motif B
VV 629 – 2% E, 1% A, 9% T, 4% I, 1% L, 83% V
Motif B
TT 630 – 2% A, 4% C, 89% T, 4% V
Motif B
- KK 631 – 100% K
NTP channel; Motif B
RR 632 – 98% R, 1% Q, 1% L
NTP channel; Motif B
SS 633 – 1% N, 68% S, 1% A, 3% C, 27% P
Motif B
VV 634 – 1% T, 99% V
Motif B
MM 635 – 100% M
Motif B
- TT 636 – 94% T, 6% V
Motif B
LL 637 – 1% F, 97% L, 2% V
Motif B
AA 638 – 2% S, 73% A, 1% T, 2% V, 21% P
Motif B
YY 639 – 100% Y
Motif B
GG 640 – 2% S, 98% G
Motif B
640
SS 641 – 73% S, 19% A, 6% G, 1% V
Motif B
KK 642 – 69% K, 10% R, 2% E, 1% Q, 3% S, 1% A, 14% T EE 643 – 10% K, 4% R, 60% E, 6% Q, 12% A, 1% T, 5% L, 1% V, 1% P FF 644 – 3% R, 5% S, 46% Y, 46% F GG 645 – 9% S, 90% G, 1% L- FF 646 – 1% A, 7% C, 1% M, 89% F, 1% V RR 647 – 14% K, 36% R, 3% Q, 9% S, 13% A, 4% C, 1% G, 13% T, 1% F, 2% L, 4% V QQ 648 – 5% K, 49% D, 21% E, 1% N, 17% Q, 4% S, 1% A, 1% T QQ 649 – 92% Q, 8% Y VV 650 – 1% F, 18% I, 21% L, 60% V- LL 651 – 16% R, 3% D, 2% E, 1% Q, 1% S, 15% M, 3% Y, 14% F, 1% I, 42% L EE 652 – 3% K, 18% D, 64% E, 2% Q, 4% S, 1% G, 5% T, 1% I, 1% V DD 653 – 1% K, 91% D, 3% E, 4% A TT 654 – 3% A, 49% T, 1% Y, 1% F, 40% I, 5% V II 655 – 1% K, 1% E, 2% S, 1% A, 53% I, 5% L, 36% V- QQ 656 – 22% K, 23% R, 1% H, 2% D, 1% E, 4% N, 24% Q, 1% A, 9% M, 7% T, 2% W, 1% F, 1% I PP 657 – 10% K, 1% R, 2% D, 5% E, 1% L, 81% P AA 658 – 3% K, 1% R, 2% D, 1% N, 2% S, 71% A, 1% G, 1% M, 9% W, 3% Y, 1% I, 3% L, 1% V
Begin insertion
II 659 – 15% K, 7% R, 1% N, 4% A, 9% M, 1% T, 44% I, 13% L, 6% V DD 660 – 1% K, 3% R, 57% D, 10% E, 2% N, 6% Q, 3% S, 6% A, 1% G, 2% T, 1% F, 1% I, 5% L 660
SS 661 – 9% K, 3% R, 1% H, 9% D, 10% E, 20% N, 19% S, 17% A, 10% G, 1% M, 2% T GG 662 – 5% K, 1% H, 1% D, 1% E, 86% G, 1% M, 5% P
Surface Loop
KK 663 – 37% K, 3% R, 1% H, 9% D, 18% E, 4% Q, 9% S, 2% A, 4% G, 6% T, 1% Y, 1% L, 4% V
Surface Loop
GG 664 – 2% K, 4% R, 1% H, 7% D, 10% E, 1% Q, 3% S, 9% A, 51% G, 4% T, 2% L, 1% V, 3% P
Surface Loop
LL 665 – 12% H, 9% D, 2% E, 4% N, 5% Q, 6% S, 12% A, 1% G, 4% M, 5% T, 7% Y, 19% F, 14% L, 1% V
Surface Loop
- MM 666 – 6% N, 1% A, 1% G, 42% M, 2% T, 4% W, 5% F, 1% I, 5% V, 31% P
Surface Loop
FF 667 – 9% W, 90% F, 1% L TT 668 – 1% K, 1% R, 8% D, 3% E, 2% N, 6% S, 2% A, 14% G, 40% T, 1% Y, 2% I, 2% L, 3% V, 14% P QQ 669 – 1% K, 3% H, 29% D, 12% E, 9% N, 20% Q, 10% S, 3% A, 2% G, 6% T, 1% I, 3% P PP 670 – 2% K, 2% R, 1% H, 2% D, 3% E, 15% A, 22% G, 1% I, 6% L, 3% V, 41% P- NN 671 – 1% K, 3% R, 1% H, 2% D, 23% N, 14% Q, 12% S, 2% A, 7% G, 2% M, 1% T, 6% W, 11% Y, 12% F, 2% P QQ 672 – 7% K, 3% R, 2% D, 6% E, 2% N, 59% Q, 2% S, 11% A, 2% G, 1% T, 1% L, 3% P
Begin insertion
AA 673 – 2% N, 6% S, 69% A, 9% C, 1% G, 4% M, 1% T, 3% Y, 3% F, 1% V AA 674 – 19% S, 68% A, 9% C, 1% T, 2% I, 1% V GG 675 – 33% R, 3% E, 4% N, 12% Q, 10% S, 9% A, 24% G, 1% T, 1% I, 2% L, 1% V- YY 676 – 11% W, 69% Y, 19% F, 1% L MM 677 – 74% M, 26% L AA 678 – 1% Q, 3% S, 79% A, 17% G KK 679 – 47% K, 1% R, 7% H, 3% D, 6% N, 2% Q, 6% S, 3% A, 18% G, 1% T, 1% I, 2% L, 1% P LL 680 – 1% K, 6% R, 11% H, 6% A, 1% C, 3% M, 71% L 680
II 681 – 88% I, 1% L, 11% V WW 682 – 99% W, 1% Y EE 683 – 1% K, 38% D, 26% E, 10% N, 4% Q, 3% S, 2% A, 1% G, 4% T, 1% I, 10% V SS 684 – 35% S, 52% A, 10% C, 1% G, 1% I, 1% V VV 685 – 2% C, 1% M, 1% T, 11% I, 4% L, 81% V- SS 686 – 3% R, 1% H, 1% E, 7% N, 4% Q, 38% S, 2% A, 38% G, 4% T VV 687 – 14% K, 2% D, 21% E, 12% Q, 3% S, 3% A, 7% T, 1% L, 36% V TT 688 – 1% E, 46% T, 1% I, 52% V VV 689 – 2% I, 9% L, 89% V VV 690 – 1% K, 1% R, 1% S, 1% T, 3% I, 1% L, 91% V- AA 691 – 29% K, 3% S, 68% A AA 692 – 3% S, 97% A VV 693 – 1% K, 21% R, 1% A, 7% G, 2% M, 67% V EE 694 – 1% H, 9% D, 64% E, 1% N, 4% Q, 2% S, 4% A, 10% G, 4% L, 1% V AA 695 – 91% A, 6% G, 1% T, 1% I- MM 696 – 100% M NN 697 – 20% K, 1% R, 2% H, 17% D, 11% E, 24% N, 2% Q, 3% S, 5% A, 10% G, 2% L, 2% V WW 698 – 99% W, 1% F LL 699 – 1% F, 99% L KK 700 – 20% K, 2% R, 78% Q 700
SS 701 – 30% K, 3% R, 2% H, 10% D, 9% E, 4% Q, 17% S, 12% A, 6% G, 5% T, 2% V AA 702 – 12% S, 61% A, 3% C, 1% G, 2% M, 2% T, 2% I, 1% L, 16% V AA 703 – 7% S, 89% A, 3% T KK 704 – 60% K, 17% R, 3% Q, 9% S, 5% A, 3% G, 1% T, 2% V LL 705 – 1% K, 2% R, 1% H, 1% S, 4% A, 1% M, 3% T, 6% I, 70% L, 10% V- LL 706 – 2% S, 24% A, 4% M, 5% I, 54% L, 10% V AA 707 – 24% S, 61% A, 3% C, 3% G, 6% T, 2% V AA 708 – 29% K, 1% R, 2% D, 1% N, 3% Q, 20% S, 35% A, 1% G, 6% T, 1% V EE 709 – 1% K, 83% E, 2% N, 4% Q, 1% S, 4% A, 2% T, 1% I, 1% P VV 710 – 2% I, 98% V- KK 711 – 85% K, 8% A, 4% I, 2% V DD 712 – 77% D, 2% E, 10% C, 10% T KK 713 – 96% K, 4% V
Surface Loop
KK 714 – 82% K, 2% R, 6% D, 4% E, 2% Q, 2% I, 2% V
Surface Loop; Begin insertion
TT 715 – 2% K, 2% D, 4% N, 2% S, 4% G, 85% T
Surface Loop
- GG 716 – 58% K, 4% D, 2% N, 34% G, 2% P
Surface Loop
EE 717 – 2% K, 6% D, 66% E, 6% N, 4% Q, 2% A, 6% T, 2% L, 6% V II 718 – 2% Q, 34% I, 64% V LL 719 – 2% I, 86% L, 12% V RR 720 – 60% K, 40% R 720
KK 721 – 18% K, 4% H, 2% E, 8% N, 2% S, 8% A, 4% G, 54% P RR 722 – 1% K, 22% R, 2% D, 9% E, 4% N, 1% Q, 2% S, 14% A, 15% C, 28% G, 2% T CC 723 – 3% K, 2% H, 3% Q, 1% S, 22% C, 29% M, 40% L AA 724 – 24% A, 5% V, 70% P VV 725 – 1% A, 3% C, 1% T, 18% I, 2% L, 74% V- HH 726 – 1% K, 16% R, 32% H, 5% N, 5% Q, 6% S, 1% C, 7% T, 17% Y, 4% F, 3% I, 1% V WW 727 – 100% W VV 728 – 1% K, 3% E, 3% N, 2% Q, 3% S, 1% A, 1% C, 1% M, 37% T, 1% Y, 2% F, 2% I, 41% V TT 729 – 3% A, 97% T PP 730 – 1% S, 2% A, 2% T, 1% L, 94% P- DD 731 – 60% D, 2% N, 6% S, 9% A, 5% M, 2% T, 16% V GG 732 – 4% N, 95% G, 1% Y FF 733 – 2% M, 84% F, 14% L PP 734 – 4% K, 1% Q, 3% T, 1% I, 6% L, 7% V, 77% P VV 735 – 1% A, 2% I, 97% V- WW 736 – 14% Q, 1% C, 12% M, 60% W, 2% Y, 5% L, 6% V QQ 737 – 99% Q, 1% S EE 738 – 64% E, 6% S, 22% A, 2% C, 1% T, 2% F, 1% L, 1% P YY 739 – 99% Y, 1% I KK 740 – 11% K, 31% R, 1% H, 1% N, 1% A, 2% C, 15% M, 6% T, 6% Y, 6% F, 1% I, 3% L, 15% P 740
KK 741 – 45% K, 7% D, 9% E, 2% Q, 2% S, 5% A, 4% T, 4% I, 3% L, 18% V
RNA exit channel
PP 742 – 5% K, 2% R, 1% E, 1% N, 11% Q, 9% S, 3% A, 2% C, 5% M, 4% T, 1% Y, 2% F, 12% L, 4% V, 37% P II 743 – 14% K, 1% R, 16% D, 23% E, 8% N, 2% Q, 4% S, 2% A, 4% T, 5% I, 3% L, 17% V QQ 744 – 12% K, 1% H, 1% D, 32% Q, 12% S, 9% A, 3% G, 1% M, 23% T, 2% I, 2% L, 1% V, 1% P TT 745 – 32% K, 26% R, 4% H, 4% E, 1% N, 5% Q, 2% S, 2% A, 1% G, 12% T, 1% Y, 9% V- RR 746 – 4% K, 83% R, 1% E, 3% Q, 2% S, 1% T, 1% L, 4% V LL 747 – 2% Y, 2% F, 31% I, 30% L, 34% V NN 748 – 13% K, 6% R, 1% H, 45% D, 8% E, 18% N, 4% Q, 2% S, 1% A, 1% L LL 749 – 1% S, 1% C, 6% M, 30% T, 2% F, 57% L, 1% V, 1% P MM 750 – 1% K, 6% R, 1% H, 8% A, 33% M, 20% T, 2% F, 12% I, 6% L, 10% V- FF 751 – 2% C, 67% F, 20% I, 10% L, 1% V LL 752 – 1% R, 2% H, 1% D, 13% N, 5% Q, 1% S, 5% A, 3% C, 10% G, 8% M, 49% L GG 753 – 4% K, 1% N, 7% S, 87% G, 1% T QQ 754 – 10% K, 4% R, 13% D, 2% E, 2% N, 23% Q, 21% S, 4% A, 1% G, 1% M, 9% T, 1% I, 1% L, 7% V FF 755 – 8% H, 2% Q, 4% A, 2% M, 2% Y, 33% F, 24% I, 2% L, 24% V- RR 756 – 69% R, 2% H, 1% D, 2% E, 4% N, 1% Q, 1% S, 1% A, 3% T, 1% Y, 1% F, 3% I, 5% L, 3% V
RNA exit channel
LL 757 – 2% K, 3% R, 1% H, 1% D, 1% A, 9% M, 1% T, 2% Y, 4% F, 21% I, 43% L, 11% V QQ 758 – 5% K, 22% R, 1% E, 1% N, 46% Q, 5% A, 5% T, 7% Y, 2% F, 2% L, 2% V PP 759 – 1% R, 4% S, 12% A, 4% M, 5% T, 5% F, 4% I, 30% L, 2% V, 31% P TT 760 – 2% K, 8% R, 1% N, 2% Q, 10% S, 1% G, 3% M, 60% T, 5% Y, 1% I, 3% L, 2% V 760
II 761 – 1% K, 1% R, 1% H, 1% D, 1% N, 2% S, 1% A, 1% G, 9% M, 2% T, 8% Y, 1% F, 25% I, 7% L, 38% V NN 762 – 1% K, 3% R, 1% H, 4% D, 2% E, 44% N, 5% Q, 4% S, 7% A, 1% G, 3% M, 5% T, 5% Y, 1% I, 7% L, 3% V, 1% P TT 763 – 8% K, 2% H, 3% D, 7% E, 2% N, 7% Q, 2% S, 2% A, 32% T, 2% I, 5% L, 29% V NN 764 – 7% K, 19% R, 10% H, 3% D, 10% E, 11% N, 5% Q, 5% S, 1% A, 11% G, 10% T, 1% Y, 1% I, 1% L, 3% V, 1% P KK 765 – 16% K, 4% R, 28% D, 16% E, 1% N, 3% Q, 3% S, 4% A, 11% G, 2% M, 2% T, 1% I, 4% V, 3% P
RNA exit channel
- DD 766 – 10% K, 19% D, 2% E, 4% Q, 23% S, 1% A, 3% G, 24% T, 2% L, 5% V, 5% P SS 767 – 14% K, 2% R, 21% D, 3% E, 19% N, 16% S, 1% A, 1% C, 11% G, 4% T, 1% W, 1% Y, 1% V, 3% P EE 768 – 26% K, 1% H, 4% D, 22% E, 7% N, 2% Q, 5% S, 2% A, 18% G, 8% T, 3% V, 1% P II 769 – 2% M, 70% I, 25% L, 2% V DD 770 – 91% D, 8% N, 1% S- AA 771 – 21% K, 15% R, 8% S, 37% A, 11% G, 3% T, 4% P HH 772 – 1% K, 51% R, 27% H, 2% N, 1% Q, 3% S, 8% A, 3% T, 2% L, 1% V KK 773 – 78% K, 15% R, 1% S, 5% A QQ 774 – 97% Q, 3% M EE 775 – 2% K, 1% R, 48% E, 4% Q, 9% S, 23% A, 5% G, 3% T, 3% V- SS 776 – 11% N, 10% Q, 68% S, 5% A, 4% T, 1% L GG 777 – 3% S, 4% A, 92% G II 778 – 91% I, 2% L, 7% V AA 779 – 55% S, 45% A PP 780 – 100% P 780
NN 781 – 100% N FF 782 – 14% W, 3% Y, 82% F VV 783 – 9% I, 91% V HH 784 – 100% H SS 785 – 97% S, 3% A- QQ 786 – 1% K, 1% N, 36% Q, 10% C, 33% M, 19% L DD 787 – 100% D GG 788 – 47% A, 53% G SS 789 – 10% N, 62% S, 25% A, 1% C, 2% T HH 790 – 91% H, 9% A- LL 791 – 19% M, 81% L RR 792 – 62% R, 12% Q, 21% M, 3% T, 1% I, 1% V KK 793 – 33% K, 1% R, 1% E, 4% Q, 4% A, 1% C, 23% M, 3% T, 29% L TT 794 – 1% S, 96% T, 1% F, 2% V VV 795 – 2% A, 1% C, 1% T, 12% I, 84% V- VV 796 – 1% K, 8% R, 2% H, 1% E, 12% N, 2% S, 5% A, 3% C, 3% G, 1% M, 2% I, 5% L, 53% V WW 797 – 16% K, 25% R, 35% H, 3% E, 1% S, 4% A, 1% M, 1% T, 3% W, 2% Y, 1% I, 5% L AA 798 – 9% S, 62% A, 14% C, 8% G, 1% M, 5% T, 1% L HH 799 – 8% K, 7% R, 33% H, 11% N, 2% Q, 9% S, 12% A, 1% G, 1% M, 1% T, 5% W, 4% Y, 4% F, 1% V EE 800 – 6% K, 11% R, 13% D, 42% E, 7% N, 11% Q, 3% S, 3% A, 2% G, 1% F 800
KK 801 – 23% K, 8% R, 2% H, 2% D, 16% E, 4% N, 4% Q, 5% S, 18% A, 3% C, 1% G, 2% T, 3% L, 7% V
Surface Loop
YY 802 – 2% H, 2% E, 96% Y
Surface Loop
GG 803 – 3% D, 4% N, 2% S, 1% A, 89% G
Surface Loop
II 804 – 1% M, 1% F, 64% I, 5% L, 29% V EE 805 – 10% K, 14% R, 4% H, 10% D, 24% E, 3% N, 4% Q, 3% S, 1% A, 3% G, 4% M, 16% T, 1% I- SS 806 – 4% K, 8% H, 1% E, 10% N, 1% Q, 52% S, 1% A, 23% F FF 807 – 1% W, 2% Y, 96% F, 1% L AA 808 – 18% S, 76% A, 4% G, 1% T, 1% V LL 809 – 1% C, 33% M, 1% T, 1% I, 57% L, 7% V II 810 – 92% I, 8% V
Motif C
- HH 811 – 100% H
Motif C
DD 812 – 100% D
Motif C
SS 813 – 100% S
Motif C
FF 814 – 1% S, 29% Y, 70% F
Motif C
GG 815 – 2% A, 98% G
Motif C
- TT 816 – 2% S, 1% A, 2% C, 93% T, 1% V
Motif C
II 817 – 20% H, 1% N, 3% S, 2% A, 1% C, 11% T, 48% I, 4% L, 3% V, 5% P PP 818 – 42% A, 1% L, 4% V, 53% P AA 819 – 1% H, 2% D, 2% S, 63% A, 2% C, 30% G DD 820 – 14% K, 5% R, 9% H, 42% D, 3% E, 16% N, 5% Q, 1% G, 1% W, 1% F, 1% L 820
AA 821 – 4% S, 78% A, 2% M, 10% T, 1% L, 4% V AA 822 – 1% K, 1% R, 2% H, 9% D, 18% E, 1% Q, 1% S, 7% A, 38% G, 1% T, 13% W, 1% V, 7% P NN 823 – 12% K, 1% R, 1% H, 4% E, 20% N, 7% Q, 4% S, 26% A, 1% C, 1% G, 2% M, 2% T, 3% Y, 3% F, 5% I, 3% L, 2% V LL 824 – 33% M, 2% F, 64% L, 1% V FF 825 – 1% N, 1% S, 22% A, 9% Y, 67% F- KK 826 – 51% K, 25% R, 2% H, 3% D, 2% E, 1% N, 7% Q, 2% A, 1% M, 2% T, 2% V, 1% P AA 827 – 3% S, 54% A, 4% C, 9% G, 7% T, 7% Y, 4% F, 3% I, 9% V VV 828 – 4% I, 23% L, 73% V RR 829 – 100% R EE 830 – 2% K, 1% R, 2% D, 90% E, 3% Q, 1% A- TT 831 – 13% E, 1% Q, 13% S, 13% A, 1% C, 1% G, 55% T, 2% V MM 832 – 51% M, 44% F, 2% I, 3% L VV 833 – 1% F, 8% I, 2% L, 89% V DD 834 – 7% K, 7% R, 14% D, 45% E, 8% N, 5% Q, 4% S, 1% G, 1% M, 3% T, 1% I, 2% L, 1% V TT 835 – 1% N, 1% Q, 1% S, 1% A, 35% M, 49% T, 5% I, 5% L- YY 836 – 1% H, 99% Y EE 837 – 1% K, 9% R, 1% H, 1% D, 40% E, 3% Q, 15% S, 2% A, 3% G, 22% T, 1% V SS 838 – 1% K, 3% H, 15% D, 32% E, 24% N, 5% Q, 5% S, 2% A, 8% G, 1% T, 1% F, 1% P CC 839 – 5% R, 15% H, 3% E, 44% N, 3% Q, 3% S, 1% A, 2% C, 5% T, 3% F, 14% V DD 840 – 2% R, 76% D, 1% E, 19% N, 1% Q, 1% A 840
VV 841 – 1% T, 1% I, 1% L, 90% V, 7% P LL 842 – 1% F, 13% I, 86% L AA 843 – 1% K, 3% D, 24% E, 1% N, 13% Q, 1% S, 41% A, 5% G, 1% M, 3% T, 5% L DD 844 – 2% K, 5% R, 52% D, 18% E, 3% N, 2% Q, 7% S, 3% A, 1% C, 1% G, 1% M, 1% T, 1% L, 2% V FF 845 – 98% F, 2% L- YY 846 – 18% K, 41% R, 1% E, 9% A, 1% G, 30% Y, 1% V DD 847 – 1% K, 9% R, 22% D, 47% E, 5% N, 3% Q, 3% S, 2% A, 3% T, 2% Y, 1% V QQ 848 – 3% R, 7% D, 32% E, 1% N, 54% Q, 1% G, 1% T, 1% V FF 849 – 5% M, 56% F, 16% I, 13% L, 9% V AA 850 – 3% K, 1% D, 18% E, 1% N, 2% Q, 1% S, 27% A, 1% C, 18% M, 3% T, 2% W, 1% Y, 9% I, 7% L, 5% V- DD 851 – 1% K, 1% R, 42% D, 13% E, 1% N, 4% Q, 2% S, 14% A, 1% G, 3% M, 1% W, 2% Y, 5% L, 1% V, 7% P QQ 852 – 1% R, 1% D, 1% N, 78% Q, 2% A, 1% G, 5% M, 3% T, 1% F, 1% I, 5% L LL 853 – 1% S, 1% C, 1% M, 5% T, 5% I, 87% L HH 854 – 55% H, 8% D, 1% E, 10% S, 8% G, 3% T, 1% L, 13% P EE 855 – 10% D, 76% E, 1% Q, 1% A, 1% G, 1% T, 1% I, 1% V, 7% P- SS 856 – 8% K, 6% H, 5% D, 8% E, 1% N, 41% S, 4% A, 7% G, 18% T, 1% V QQ 857 – 4% K, 2% E, 7% N, 62% Q, 2% S, 10% A, 4% T, 1% F, 1% I, 6% L, 1% V
Begin insertion
LL 858 – 5% K, 14% R, 1% Q, 1% S, 7% A, 1% G, 8% M, 5% I, 54% L, 1% V, 1% P DD 859 – 4% K, 35% D, 40% E, 1% N, 6% Q, 1% S, 6% A, 4% G, 1% T, 1% V, 1% P KK 860 – 68% K, 2% R, 7% D, 8% E, 4% Q, 3% S, 4% A, 2% T, 1% V 860
MM 861 – 48% M, 1% T, 12% I, 36% L, 2% V PP 862 – 3% K, 1% D, 4% E, 2% A, 1% L, 88% P AA 863 – 1% K, 1% R, 7% D, 22% E, 1% Q, 5% S, 36% A, 2% M, 1% T, 1% F, 1% V, 21% P LL 864 – 1% Q, 1% S, 5% M, 2% F, 21% I, 56% L, 12% V, 1% P PP 865 – 100% P- AA 866 – 18% K, 2% R, 9% E, 7% Q, 8% S, 29% A, 1% G, 4% M, 5% T, 1% L, 2% V, 14% P KK 867 – 60% K, 11% R, 2% H, 1% D, 1% N, 2% Q, 4% S, 2% A, 7% M, 1% T, 2% F, 4% V, 1% P GG 868 – 100% G
Begin insertion
NN 869 – 10% K, 1% R, 7% D, 1% E, 23% N, 1% Q, 20% S, 2% A, 5% G, 29% T, 1% L LL 870 – 4% F, 96% L- NN 871 – 1% K, 1% H, 63% D, 8% E, 18% N, 4% Q, 1% S, 1% G, 3% V LL 872 – 34% I, 63% L, 3% V RR 873 – 2% K, 20% R, 1% H, 2% D, 13% E, 7% N, 22% Q, 16% S, 5% A, 11% T DD 874 – 4% K, 1% R, 22% D, 25% E, 1% N, 30% Q, 1% S, 3% A, 3% G, 7% L, 2% V II 875 – 3% T, 59% I, 37% V- LL 876 – 4% K, 4% R, 1% E, 1% Q, 3% A, 1% C, 2% M, 78% L, 4% V EE 877 – 36% K, 2% R, 2% H, 9% D, 30% E, 11% N, 3% Q, 4% S, 2% L SS 878 – 99% S, 1% T DD 879 – 2% K, 14% R, 36% D, 12% E, 14% Q, 1% S, 4% A, 4% L, 1% V, 10% P FF 880 – 29% Y, 71% F
FAFA
880
AA 881 – 1% S, 55% A, 14% C, 1% M, 2% T, 24% F, 2% I
FAFA
FF 882 – 100% F
FAFA
AA 883 – 100% A
FAFA