abortive cycling - Martin Lab

Insights into the Mechanism of Initial Transcription in E coli RNA Polymerase. Energetic Mechanisms Leading to Initial Complex Instability and Abortive Cycling

By Posted on September 18, 2013 Posted in Publications Tagged with abortive cycling, bacterial rna polymerase, in vitro, rna polymerase, T7 RNA polymerase, transcription

Satamita Samanta & Craig T. Martin, J. Biol. Chem. 288, 31993-32003, 2013. It has long been known that during initial transcription of the first 8-10 bases of RNA, complexes are relatively unstable, leading to the release of short abortive RNA transcripts. An …

Insights into the Mechanism of Initial Transcription in E coli RNA Polymerase. Energetic Mechanisms Leading to Initial Complex Instability and Abortive Cycling Read more »

New Insights into the Mechanism of Initial Transcription: the T7 RNA Polymerase Mutant P266L Transitions to Elongation at Longer RNA Lengths than Wild Type

By Posted on May 30, 2012 Posted in Publications Tagged with abortive cycling, in vitro, P266L, rna polymerase, T7 RNA polymerase, transcription

Luis Ramírez-Tapia & Craig T. Martin, J. Biol. Chem. 287, 37352-37361, 2012. RNA polymerases undergo substantial structural and functional changes in transitioning from sequence-specific initial transcription to stable and relatively sequence-independent elongation. Initially transcribing complexes are characteristically unstable, yielding short abortive products …

New Insights into the Mechanism of Initial Transcription: the T7 RNA Polymerase Mutant P266L Transitions to Elongation at Longer RNA Lengths than Wild Type Read more »

Direct Tests of the Energetic Basis of Abortive Cycling in Transcription

By Posted on May 30, 2011 Posted in Publications Tagged with abortive cycling, in vitro, initial transcription, initiation, rna polymerase, T7 RNA polymerase, transcription, transcription initiation

Ankit V. Vahia & Craig T. Martin, Biochemistry 50, 7015-7022, 2011. Although the synthesis of RNA from a DNA template is (and must be) a generally very stable process to enable transcription of kilobase transcripts, it has long been known that …

Direct Tests of the Energetic Basis of Abortive Cycling in Transcription Read more »

Tag: abortive cycling

Insights into the Mechanism of Initial Transcription in E coli RNA Polymerase. Energetic Mechanisms Leading to Initial Complex Instability and Abortive Cycling

New Insights into the Mechanism of Initial Transcription: the T7 RNA Polymerase Mutant P266L Transitions to Elongation at Longer RNA Lengths than Wild Type

Direct Tests of the Energetic Basis of Abortive Cycling in Transcription